DraftKings Sportsbook is offering a special Amazon TNF Three Play for tonight’s 49ers-Rams game.
The Amazon team has made their Same Game Parlay. It is as follows:
- Christian McCaffrey Under 121.5 Rush + Rec Yds
- Puka Nacua 80+ Rec Yards
- Matthew Stafford 2+ Passing TDs

DraftKings Sportsbook Game Preview
Each 3-1 in 2025, division rivals the San Francisco 49ers and Los Angeles Rams will look to get ahead through victory at SoFi Stadium on Thursday Night Football. The Rams are coming off a 27-20 home win over the Colts led by Matthew Stafford and Puka Nacua, who hooked up 13 times for 170 yards and a touchdown, before the second of two interceptions by safety Kam Curl sealed victory. Nacua is comfortably leading the league for receiving yards (503). Meanwhile, the 49ers’ latest outing ended in a surprise 26-21 home loss to the Jaguars. Brock Purdy returned to action with 309 passing yards and two touchdowns, but he also threw two interceptions and lost a fumble. Purdy will be held out on a short week, along with Ricky Pearsall and Jauan Jennings, leaving the offense considerably shorthanded. The Rams won both encounters with the 49ers last season, triumphing 27-24 at SoFi Stadium in Week 3 and 12-6 at Levi’s Stadium in Week 15.
Recent Head-To-Head History

Key Stats
- Christian McCaffrey has recorded 69+ rushing yards in each of his four previous appearances against the Rams.
- Christian McCaffrey has recorded 52+ receiving yards in each of the 49ers’ last four games.
- Puka Nacua has recorded 117+ receiving yards in each of his last five appearances at SoFi Stadium.
- Matthew Stafford has thrown two or more touchdowns in five of the Rams’ last six games.
Matchup Stats

Coverage starts at 7 p.m. ET on Prime Video.
Place your bets at DraftKings Sportsbook or by downloading the DraftKings Sportsbook app.