Week 5 of the NFL season gets rolling tonight, and DraftKings Sportsbook has plenty of 49ers vs. Rams parlays for you to choose from. Below, you’ll find a plethora of Same Game Parlays (SGPs) for this game that you can instantly add to your bet slip. Simply click “Add to Bet Slip” to be taken to DraftKings to place your bet.
You can view our full complement of parlays and same game parlays on DraftKings Network!
49ers vs. Rams Same Game Parlay Picks – NFL Week 5 Thursday Night Football
49ers-Rams and Red Sox-Yankees Parlay: Play this cross sport parlay featuring both the 49ers-Rams and Red Sox Yankees Wild Card Game tonight!
- Aaron Judge 2+ Hits + Runs + RBIs
- Christian McCaffrey Over 53.5 Rec Yards
- Trevor Story 2+ Hits + Runs + RBIs
- Kyren Williams 2+ Receptions
49ers vs. Rams SGP: Back these players to all have a reception in the first quarter!
- Davante Adams 1+ 1st Quarter Reception
- Christian McCaffrey 1+ 1st Quarter Reception
- Puka Nacua 1+ 1st Quarter Reception
- Demarcus Robinson 1+ 1st Quarter Reception
- Kyren Williams 1+ 1st Quarter Reception
Jaxon Smith-Njigba SGP: Will JSN continue his torrid start to the 2025 NFL season vs. the Cardinals tonight?
- Jaxon Smith-Njigba 100+ Rec Yards
- Jaxon Smith-Njigba 7+ Receptions
- Jaxon Smith-Njigba to Score a TD
Los Angeles Rams SGP: The Rams are big favorites tonight, bet them to win along with some player props!
- LA Rams to Win (vs SF)
- Matthew Stafford 250+ Passing Yards
- Kyren Williams 90+ Rush + Rec Yards
- Puka Nacua to Score a TD
San Francisco 49ers Parlay: Can the 49ers pull off the upset? Back it here!
- SF 49ers to Win (@ LAR)
- Mac Jones 200+ Passing Yards
- Christian McCaffrey 50+ Rushing Yards
- Christian McCaffrey to Score a TD
Puka Nacua Parlay: Nacua has been crushing it in 2025, bet him to keep it going tonight vs. 49ers
- Puka Nacua 100+ Receiving Yards
- Puka Nacua 10+ Receptions
- Puka Nacua to Score 1st TD
Thursday Night Football on Amazon Parlay: Bet this TNF Parlay!
- Christian McCaffrey Under 121.5 Rush + Rec Yds
- Puka Nacua 80+ Receiving Yards
- Matthew Stafford 2+ Passing TDs
Want even more action? Check out all of our NFL parlays on DraftKings Network for updated odds and fresh builds.
How to Watch 49ers vs. Rams
Here’s everything you need to know to watch the Week 5 Thursday Night Football matchup between the San Francisco 49ers and Los Angeles Rams, including kickoff time, TV channel, and streaming options.
Date: Thursday, October 2
Location: SoFi Stadium, Inglewood, CA
Kickoff: 8:15 p.m. ET
TV: Amazon Prime Video
Streaming: Amazon Prime Video
