NFL Week 4 is almost in the books, pending the Monday night matchups, but the opening odds for Week 5 are up on DraftKings Sportsbook and it’s time to give them a look.
There is one game on Thursday. There are 12 games on Sunday, and there is one Monday night game. The byes start this week, so Atlanta, Chicago, Green Bay and Pittsburgh are all off.
Here’s the full list of Week 5 odds on DraftKings Sportsbook.
Thursday Game, October 2
49ers at Rams – 8:15 p.m. ET
Odds on Sunday, September 29
| Spread | Total | Moneyline | |
| SF 49ers | +5.5 -108 | O 46.5 -105 | +200 |
| LA Rams | -5.5 -112 | U 46.5 -115 | -245 |
The Rams bounced back from their Week 3 loss to Philadelphia with a 27-20 win over Indianapolis. Matthew Stafford threw for 375 yards! San Francisco lost its first game of the season to Jacksonville in Week 4. Brock Purdy threw for 309 yards and two touchdowns but had two interceptions and a fumble. These division rivals are intimately familiar with each other. Too bad both teams are not at full strength. The spread was -3 after Sunday’s games. On Monday, news came out that Brock Purdy was dealing with toe soreness and his status for Week 5 is uncertain.
Sunday Early Games – October 5
Raiders at Colts – 1 p.m. ET
Odds on Sunday, September 29
| Spread | Total | Moneyline | |
| LV Raiders | +6.5 -108 | O 47.5 -105 | +235 |
| IND Colts | -6.5 -112 | U 47.5 -115 | -290 |
After winning their season opener in Foxborough, the Las Vegas Raiders have lost three straight, with the most recent being a 25-24 loss to Chicago at home. Geno Smith threw three touchdowns in garbage time during Week 3. In Week 4, Smith threw three interceptions that were just garbage. Ashton Jeanty did break out for 138 yards on 21 carries with a touchdown while hauling in two touchdown receptions. That was against the Bears, though, The Indianapolis Colts are a much better team on both sides of the ball. The Colts did experience their first L of the season in Los Angeles to the Rams, 27-20. The Rams are a very good football team, so no shame in that one on the road. Now the Colts return home.
Vikings at Browns – 1 p.m. ET
Odds on Sunday, September 29
| Spread | Total | Moneyline | |
| MIN Vikings | -4.5 -108 | O 36.5 -112 | -218 |
| CLE Browns | +4.5 -112 | U 36.5 -108 | +180 |
Both teams lost in Week 4, but Minnesota has to recover from playing in Ireland. Now the Vikings have to travel to Cleveland to face a ferocious Browns defense with Carson Wentz under center. The Detroit Lions easily defeated the Browns, 34-10, but the defense held Detroit to 168 yards passing and 109 yards on the ground. One of the touchdowns was a special teams score.
Giants at Saints – 1 p.m. ET
Odds on Sunday, September 28
| Spread | Total | Moneyline | |
| NY Giants | +1.5 -118 | O 40.5 -115 | -102 |
| NO Saints | -1.5 -102 | U 40.5 -105 | -118 |
The strength of the Giants defense is the defensive line, and they wreaked havoc on a hobbled Chargers offensive line, helping to get the first win of the season. Jaxson Dart only threw 20 times for 111 yards and took five sacks, but he threw a touchdown without an interception and rushed 10 times for 54 yards and another touchdown. The big news for New York is the injury to Malik Nabers. I’m sad now, but not as sad as fans down in New Orleans, as the Saints remain winless and have scored over 20 points just once this season. I remember back in the day when Saints fans would come to games with bags over their heads. The headgear could be making a comeback. On Sunday, the Giants were favored by 2.5 points. On Monday, Malik Nabers was ruled out for the season due to a torn ACL.
Cowboys at Jets – 1 p.m. ET
Odds on Sunday, September 29
| Spread | Total | Moneyline | |
| DAL Cowboys | -2.5 -110 | O 46.5 -118 | -135 |
| NY Jets | +2.5 -110 | U 46.5 -102 | +114 |
Dallas plays on Sunday night against a tough and physical Packers team that got beat up by the Cleveland Browns the prior week. The Jets play on Monday night against their division rival Miami Dolphins.
Broncos at Eagles – 1 p.m. ET
Odds on Sunday, September 29
| Spread | Total | Moneyline | |
| DEN Broncos | +3.5 -105 | O 43.5 -115 | +170 |
| PHI Eagles | -3.5 -115 | U 43.5 -105 | -205 |
The Broncos should take care of Cincinnati at home on Monday night. That would snap a two-game losing streak. Denver has been unimpressive to start the season, but it could become a playoff contender with a victory over the undefeated Eagles. Both teams sport excellent defenses, but can the Broncos line matchup up to the Eagles line? Philadelphia was favored by 5.5 points on Sunday night.
Dolphins at Panthers – 1 p.m. ET
Odds on Sunday, September 29
| Spread | Total | Moneyline | |
| MIA Dolphins | -1.5 -105 | O 46.5 -115 | -120 |
| CAR Panthers | +1.5 -115 | U 46.5 -105 | +100 |
Miami plays on Monday night. After shutting out the Atlanta Falcons, 30-0, in Week 3 at home, the Panthers traveled to New England in Week 4 and got smashed, 42-13. Carolina has played three of four games on the road and lost all three. This game is at home.
Texans at Ravens – 1 p.m. ET
Odds on Sunday, September 29
| Spread | Total | Moneyline | |
| HOU Texans | +3.5 -110 | O 42.5 -118 | +154 |
| BAL Ravens | -3.5 -110 | U 42.5 -102 | -185 |
Houston finally got its first win of the season at home against Tennessee. Don’t make too much of it because the Titans are in straight rebuild mode with a rookie quarterback. Now the Texans have to travel to Baltimore against an angry Ravens team that got humbled in Kansas City and is now 1-3 on the season. Lamar Jackson exited Week 4’s game early due to a hamstring issue. His status is unknown for Week 5. Cooper Rush could be getting the start. Defensive tackle Nnamdi Madubuike was lost for the season so there’s a little more hope for Houston… Well, the spread is only 3.5 points.
Sunday Late Games – October 5
Titans at Cardinals – 4:05 p.m. ET
Odds on Sunday, September 29
| Spread | Total | Moneyline | |
| TEN Titans | +9.5 -110 | O 41.5 -105 | +350 |
| ARI Cardinals | -9.5 -110 | U 41.5 -115 | -455 |
Tennessee has yet to win a game, scored at least 20 points only once and got shut out in Week 4. No. 1 overall pick Cam Ward is completing only 51.2% of his passes for 614 yards, two touchdowns and two interceptions. After winning the first two games of the season against cupcakes (New Orleans and Carolina), Arizona lost to two division rivals (San Francisco and Seattle). The Cardinals get another cupcake in Week 5.
Buccaneers at Seahawks – 4:05 p.m. ET
Odds on Sunday, September 29
| Spread | Total | Moneyline | |
| TB Buccaneers | +3 -108 | O 44.5 -108 | +136 |
| SEA Seahawks | -3 -112 | U 44.5 -112 | -162 |
Tampa Bay is now 3-1 after losing 31-25 to the Philadelphia Eagles. Not a bad effort considering all the injuries the Buccaneers are enduring currently. They get another tough matchup against a Seahawks team that has been playing excellent defense and will be at home in front of the 12th man. After dropping its opener to San Francisco, Seattle has rattled off three straight wins.
Lions at Bengals – 4:25 p.m. ET
Odds on Sunday, September 29
| Spread | Total | Moneyline | |
| DET Lions | -8.5 -110 | O 49.5 -110 | -395 |
| CIN Bengals | +8.5 -110 | U 49.5 -110 | +310 |
After the sky was falling following the Week 1 loss in Green Bay, the sky is back in its normal place after three straight victories — a blowout of Chicago, an impressive win in Baltimore and a 34-10 victory at home over Cleveland. The offense wasn’t firing on all cylinders in Week 4, but that’s because the Browns have one of the best defenses in the league. Unfortunately, the offense is the exact opposite. Cincinnati plays on Monday night … in Denver. It will likely be 2-2 heading into Week 5, 2-3 after the Detroit game and 2-4 after going to Green Bay in Week 6.
Commanders at Chargers – 4:25 p.m. ET
Odds on Sunday, September 29
| Spread | Total | Moneyline | |
| WAS Commanders | +3 -112 | O 47.5 -110 | +130 |
| LA Chargers | -3 -108 | U 47.5 -110 | -155 |
Both Jayden Daniels and Marcus Mariota are 1-1 this season, but Daniels is expected to be back for this one. The Chargers dropped their first game in Week 4 against a Giants defensive line that wreaked havoc on the hobbled Chargers offensive line. Left tackle Joe Alt left Week 4’s game early. Los Angeles lost Rashawn Slater in training camp.
Sunday Night Game – October 5
Patriots at Bills – 8:20 p.m. ET
Odds on Sunday, September 29
| Spread | Total | Moneyline | |
| NE Patriots | +7.5 -105 | O 49.5 -112 | +295 |
| BUF Bills | -7.5 -115 | U 49.5 -108 | -375 |
New England easily dispatched Carolina in Week 4, 42-13. Week 5 will elevate the competition from JV to varsity, as the Buffalo Bills are undefeated and a legitimate Super Bowl contender.
Monday Night Game – October 6
Chiefs at Jaguars – 8:15 p.m. ET
Odds on Sunday, September 29
| Spread | Total | Moneyline | |
| KC Chiefs | -3.5 -105 | O 45.5 -110 | -180 |
| JAX Jaguars | +3.5 -115 | U 45.5 -110 | +150 |
Kansas City lost by six to the Chargers and by three points to the Eagles. Granted, both of those teams are very good. After getting back to the winning ways fairly easily against the Giants in Week 3, the Chiefs were impressive against Baltimore in Week 4, getting the 37-20 win. That Patrick Mahomes guy is pretty, pretty good. Jacksonville is now 3-1 after a 26-21 win in San Francisco. If the Jaguars take care of the Chiefs, then maybe we can start talking.
