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Fantasy College Football Picks: Top DraftKings Week 5 CFB DFS Targets, Values for 9/27/25

Fantasy College Football Picks: Top DraftKings Week 5 CFB DFS Targets, Values for 9/27/25

Published:

By: Blake Krass

College football Week 5 has a great slate of games on the featured DFS slate. You can play weekly DFS contests at DraftKings for the duration of the season.

DraftKings has a CFB $225K Saturday Kickoff contest, with $50,000 going to first place. You can enter the contest for just $20 here.

Quarterback

Stud

Devon Dampier, Utah at WVU, $9,600

Devon Dampier and Utah are coming off their first loss of the season against Texas Tech. This is a great chance for them to bounce back against West Virginia. Utah still has a great chance of making the College Football Playoff if it gets its season back on track. Unlike against the stout Texas Tech defense, Dampier should be able to use his legs against West Virginia. Dampier was averaging over six yards per carry in his first three games, but ran for just 2.5 YPC against Texas Tech. West Virginia just played a great dual-threat quarterback, Kansas’ Jalon Daniels. In that game, Daniels threw for three touchdowns and ran for 69 yards. Dampier should have a big game and get Utah back to its winning ways.

Value

Brendan Sorsby, Cincinnati at Kansas, $6,400

Brendan Sorsby has had a strong start to the season in Cincinnati. Through three games, he has eight passing touchdowns and four rushing touchdowns, with only one interception. Kansas ranks 85th in the country in defensive EPA/pass. Sorsby should be able to move the ball through the air, then use his legs when the opportunity arises. The only competent offense that Kansas has faced this season is Missouri, where Bo Pribula threw for 334 yards and three touchdowns. Sorsby should have a big game and is a strong value play this week.

Running Back

Stud

Jeremiyah Love, Notre Dame at Arkansas, $8,500

Jeremiyah Love is one of the best running backs in the country. He rushed for over 1,100 yards and 17 touchdowns last season, helping Notre Dame get to the national title game. It was a tough start to the season for Notre Dame, facing high-level defenses in its first two games, Miami and Texas A&M. However, as soon as it went up against a subpar defense in Week 3 against Purdue, Love had an explosive game. He ran for 157 yards and two scores against the Boilermakers, and could top those numbers against Arkansas. Arkansas ranks 107th in the nation in defensive EPA/rush and 127th in defensive rushing success rate. It should be a monster game for Love against the Razorbacks.

Value

Jadarian Price, Notre Dame at Arkansas, $6,300

This is the rare case where two players from the same position on the same team are both worth a play this week. While Jeremiyah Love is the household name, Jadarian Price is an exceptional running back in his own right. The running back duo has become a popular trend in college football. Last season, Ohio State won the national title with two running backs who then got drafted in the second round of the 2025 NFL Draft. That is the model that Notre Dame is aspiring for with Love and Price. Love is the bellcow back, but Notre Dame has no problem giving Jadarian Price the important goal-line touches. Price has five rushing touchdowns over the last two games, with more touchdowns than Love on the season. In the rare DFS handcuff move, it could be worthwhile to start both Love and Price against one of the worst run defenses in the country.

Wide Receiver

Stud

Cam Coleman, Auburn at Texas A&M, $6,900

Cam Coleman is a superstar at wide receiver for Auburn. He is in a run-heavy offense at Auburn, but still makes his impact known despite minimal chances. He just faced Oklahoma, one of the best defenses in the country. Despite only having three receptions, Coleman turned that into 88 yards and a touchdown. That makes back-to-back games with a score for Coleman. This Texas A&M defense has struggled a bit this season, giving up over 28 points per game despite two of its three opponents being relatively easy competition. Notre Dame’s CJ Carr threw for nearly 300 yards against the Aggies, showing their vulnerability on the back end. If Auburn wants to hang in this game, it needs Cam Coleman to produce, and he should do so for the fourth straight game.

Value

Harrison Wallace III, Ole Miss vs. LSU, $5,000

Harrison Wallace III has been a hit transfer for Ole Miss. Wallace was formerly at Penn State, but moved to a more pass-heavy offense to boost his NFL stock. He had a quiet game against Tulane, but in the three games prior, he averaged 113 receiving yards per game. Wallace has two touchdowns through four games and should be a scoring threat against LSU. The Tigers have been tough against the run, ranking 15th in the nation in defensive EPA/rush. If Ole Miss wants to score, it needs to be able to throw the football down the field. That means Wallace could be in for a big game in this pivotal SEC matchup.

Flex/Superflex

You can use any of the other names I listed in the above categories for the flex or superflex positions. However, here are a few more names, just in case.

Stud

Taylen Green, QB, Arkansas vs. Notre Dame, $9,100

Taylen Green has been one of the standout players in the country through the first month of the season. Arkansas has fallen short in its past two games, but through no fault of Green. The senior ranks eighth in the nation in passing yards, third in passing touchdowns, and leads all quarterbacks in the country in rushing yards. He can do it all for Arkansas, and needs to do it all due to the terrible Razorbacks’ defense. Arkansas gets into a shootout every game, and it will be another shootout against Notre Dame. The Fighting Irish will be able to move the ball, meaning Arkansas needs Taylen Green to hang a big number if they want to get a win. The normally great Notre Dame defense is anything but great this season. That unit ranks 130th in the nation in defensive EPA/pass. It should be a monster game for Green, win or lose.

Value

KC Concepcion, WR, Texas A&M vs. Auburn, $5,700

The Aggies hit on transfer wide receiver KC Concepcion. Concepcion came over from NC State during the offseason and has hit the ground running in College Station. He has at least 72 receiving yards in all three games this season, plus three total touchdowns. He has performed both against weaker competition and in Notre Dame’s big game against Notre Dame. Now, as SEC play gets underway, Concepcion will have a key role to play as Texas A&M hopes to make the College Football Playoff. This game in particular will be key for Concepcion, as it should be a pass-heavy approach from the Aggies. Auburn ranks second in the country in defensive EPA/rush, but 114th in defensive EPA/pass. Texas A&M will attack through the air, meaning Concepcion should keep his consistent run of performances going.

Blake Krass has contributed to DraftKings since 2024, and is a content creator with a specialty in sports betting. Blake primarily focuses on college football and NFL coverage but will also be covering college basketball, the NBA, MLB and more. Prior to arriving at DK, Blake was a sports betting writer for The Action Network.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and customer (my username is blakekrass) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.