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Boston Red Sox vs. Toronto Blue Jays prediction, pick for Wednesday 9/24/25

Boston Red Sox vs. Toronto Blue Jays prediction, pick for Wednesday 9/24/25

Published:

By: Bryan Armetta

Things are heating up in the AL East. Toronto’s division lead over the Yankees sits at just one game. That makes tonight’s contest pivotal for the Blue Jays if they hope to avoid the wildcard round. Winning won’t be easy against the Red Sox and staff ace Garrett Crochet. Can Boston pull off another road victory at Rogers Centre? Below, I’ve laid out my preview, prediction, and best bet for Wednesday’s meeting between the Boston Red Sox and the Toronto Blue Jays.

Boston is favored (-127) over Toronto, with the over/under set at 7.5 runs. Let’s break down which side has the edge on DraftKings Sportsbook entering tonight’s contest.

Red Sox vs. Blue Jays prediction, preview

The headliner in this one will be Crochet, making perhaps his finals tart of the regular season. Through 197.1 innings of work, the left-hander has notched 2.69 ERA, 1.05 WHIP and league-leading 249 strikeouts. If not for Tarik Skubal, the 26-year-old would be in pole position to win his first career Cy Young award. Granted, the All-Star has looked somewhat mortal recently, surrendering three runs in each of his previous two starts. Crochet has held the Blue Jays to three earned runs over 12.2 innings this season (2.13 ERA).

Toronto has spent most of 2025 as a lethal offensive unit, especially at home. However, that hasn’t been the case in recent weeks. During their last ten games, the Blue Jays have only scored 36 total runs. That’s the seventh-lowest mark in baseball in that time. Canada’s team has scored only one run in three of their last four contests. However, they own the league’s fourth-highest OPS vs. left-handed pitching this season.

The bigger question for the Jays tonight isn’t on offense. Starting pitcher Max Scherzer has had plenty of solid moments with Toronto. However, his most recent outing vs. Kansas City was a disaster (0.2 IP, 7 ER). The future Hall of Famer has allowed more than three runs in four of his last five appearances. That doesn’t bode well heading into a matchup with an elite lineup. The Red Sox rank sixth in baseball with 4.85 runs per game on the road. In 13 career meetings with Boston, Scherzer has accounted for a 5.67 ERA.

Red Sox vs. Blue Jays pick, best bet

Best Bet: Red Sox -1.5 (+134)

It’s not easy to go against the Jays, especially considering their American League-leading 50-26 record at home. Still, Crochet is simply too dominant to fade tonight. In addition, Scherzer’s recent struggles are cause for concern. Expect a comfortable win for the Red Sox on Wednesday.

Bryan Armetta is a New York-based writer that has spent over eight years in sports media. Working for DraftKings since 2024, he currently serves as a writer, editor and analyst for all things sports and pop culture. Bryan specializes in MLB, NBA, NFL, college sports and entertainment content. Prior to his time at DKN, he worked for MLB Network, NHL Network and SiriusXM Sports.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.