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Liverpool vs. Southampton prediction, pick for Tuesday 9/23/25

Liverpool vs. Southampton prediction, pick for Tuesday 9/23/25

Published:

By: Ciaran Doyle

The third round of the Carabao Cup continues on Tuesday as Liverpool host Southampton.

The Reds are -700 moneyline favorites on DraftKings Sportsbook for this one, with a draw available at +600. Fancy a Saints upset? The Championship side are +1200 on the moneyline. The game is slated to kick off at 3:00 p.m. ET.

Liverpool vs. Southampton Prediction, Pick

This bet can be found under the “Match Props” tab. I am backing Liverpool to win this one comfortably, and I think they will be able to keep a clean sheet in the process. Yes, there will likely be massive rotation from Saturday’s Premier League game, but the Reds have one of the best squads in Europe. Even if they play every single backup, I still think they would dominate this one.

It’s been a rough last 12 months for Southampton. They finished bottom of the Premier League table last season, resulting in relegation to the Championship. Things are even worse this season, as now they are even struggling in the second division of English football. They have won just one of their opening six league games, which puts them in 19th place in the Championship.

Meanwhile, Liverpool are the reigning champions of England and have won all five of their Premier League games this season. I would be shocked if this one was close, and it’s hard to see past a Liverpool win. The question is, can they keep a clean sheet?

The Reds have only managed to keep two clean sheets in their first five games, but that’s also against Premier League opposition. Southampton used to be of that quality, but sadly not anymore. Liverpool have won each of the last four meetings between these two sides, but have only kept a clean sheet in one of those. Those games were against a Saints side that were in a much better place than they are right now, so I expect another Liverpool win, but this time with zero goals conceded.

I’m predicting a 3-0 win for the Reds as they cruise into the fourth round of this competition.

The Pick: No- Both Teams to Score (-120)

Ciaran has been an editor for the DraftKings Network team since 2023. He graduated from the University of Arizona before attending Arizona State University for his master’s degree in sports journalism. Ciaran previously covered Phoenix Rising FC for Cronkite News before joining DraftKings. He is passionate about sports betting, and his biggest focus has always been on the NFL and soccer. You can find him on X at @Ciaran_Doyle7.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is ciarandoyle77) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.