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Fantasy College Football Picks: Top DraftKings Week 4 CFB DFS Targets, Values for 9/20/25

Fantasy College Football Picks: Top DraftKings Week 4 CFB DFS Targets, Values for 9/20/25

Updated:

By: Blake Krass

College football Week 4 has a great slate of games on the featured DFS slate. You can play weekly DFS contests at DraftKings for the duration of the season.

DraftKings has a CFB $225K Saturday Kickoff contest, with $50,000 going to first place. You can enter the contest for just $20 here.

Quarterback

Stud

Taylen Green, Arkansas at Memphis, $8,400

Taylen Green has had a sensational start to the season. Arkansas ranks eighth in the country in offensive EPA/play thanks to Green’s great play. He has 11 passing touchdowns through three games, tied for the national lead. He is averaging over 288 passing yards per game, a top-20 mark in the country. Green is also great with his legs, averaging over 100 rushing yards per game with two rushing touchdowns on the season. This week, he faces a Memphis team that he should be able to attack through the air. They rank 80th in the nation in defensive EPA/pass and should get shredded by Green, leading to another big statistical game for the Arkansas quarterback.

Value

Dylan Raiola, Nebraska vs. Michigan, $6,100

Dylan Raiola is off to a strong start to his sophomore season. The Nebraska signal-caller didn’t have the season that he hoped for last season at Nebraska, but he learned a lot from his freshman year and has shown signs of massive improvement. Raiola is averaging over 275 passing yards per game, has an 8-0 TD-INT ratio and his team is 3-0. This will be their toughest test yet against Michigan, although this is not the Michigan defense of the last couple of years. The pieces that they have lost to the NFL over the past several years have taken a toll, as shown by John Mateer when they faced Oklahoma. Mateer was able to move the ball against the Wolverines, and so should Raiola on Saturday.

Running Back

Stud

Kewan Lacy, Ole Miss vs. Tulane, $7,700

Kewan Lacy has been great for Ole Miss to start the season. He rushed for 108 yards and three scores in his first game for the Rebels, then rushed for 138 yards and a touchdown in his first SEC game against Kentucky. Last week against Arkansas, they made an effort to stop the run, but Ole Miss was able to use Lacy in the passing game for the first time this season. He finished the game with 84 all-purpose yards and a score. Ole Miss should lean on Lacy in this game. Tulane has been solid against the pass this season, but ranks 88th in the country in defensive EPA/rush. The Rebels should be able to jump out to a lead in this game and just feed Lacy the entire second half.

Value

Devin Mockobee, Purdue at Notre Dame, $5,000

Devin Mockobee is an experienced rusher for Purdue. The senior ranks fifth all-time in rushing yards at Purdue and should keep climbing that list this season. Normally, it would be tough to go against Notre Dame as a Purdue running back. However, the Fighting Irish have struggled defensively this season. Last season, they had one of the best defenses in the nation, which led them to the national title game. This season, Notre Dame ranks 131st in defensive EPA/play. They lost some key pieces to the NFL, but none more important than defensive coordinator Al Golden, who is now with the Cincinnati Bengals. Their new DC, Chris Ash, is not living up to the job so far. Notre Dame has had a tough start to the season, sitting at 0-2 with their season essentially over before it even began. If they have a defeated attitude, Mockobee could really take it to them on the ground.

Wide Receiver

Stud

Bryant Wesco Jr., Clemson vs. Syracuse, $6,700

Star Clemson wide receiver Antonio Williams has been out to start this season. That has made Bryant Wesco Jr. the primary target for Cade Klubnik. Through three games, Wesco is averaging 103.3 yards and a touchdown per game. While Clemson has had issues in other parts of their team, Wesco has been a bright spot, stepping up into that WR1 role. Clemson should be able to attack this Syracuse secondary, which ranks 97th in the country in defensive EPA/pass. Clemson needs to start winning games; otherwise, their season could be over fast. This is a good chance for Cade Klubnik and their offense to get rolling.

Value

Ryan Davis, Utah vs. Texas Tech, $4,600

Ryan Davis has emerged as the clear go-to target for Devon Dampier in this Utah offense. Davis has 19 catches on the season, almost twice as many as anyone else on the team. He has gone for 171 yards through three games and added a touchdown. This is a run-heavy offense with Dampier and their strong running back duo, but Davis is the pass-catcher that Dampier trusts when he does have to throw. This is Utah’s biggest game of the season against Texas Tech, which means the Utes will likely have to mix things up offensively and get Dampier to air it out. Davis should be the recipient of most of those targets and have another good game for the Utes.

Flex/Superflex

You can use any of the other names I listed in the above categories for the flex or superflex positions. However, here are a few more names, just in case.

Stud

Jeremiyah Love, RB, Notre Dame vs. Purdue, $9,000

Jeremiyah Love is one of the best running backs in the nation. It has been a brutal start to the season for Notre Dame, losing each of its first two games, both against high-level competition. Facing Purdue will be a much-needed relief from the brutal schedule they have faced so far. Love had 147 all-purpose yards and two touchdowns in their loss against Texas A&M. This game against Purdue should be another good statistical game for Love. They should jump out to a lead and then feed Love, allowing him to rack up the yardage and get in the end zone multiple times. Purdue ranks 126th in the nation in defensive EPA/play, making this the ideal game for Notre Dame to get back on track.

Value

O’Mega Blake, WR, Arkansas vs. Memphis, $6,200

O’Mega Blake has been a massive weapon for Taylen Green and the Arkansas offense so far this season. He leads the team in receptions, receiving yards and receiving touchdowns through three weeks. He has been by far Taylen Green’s favorite target. Blake has 266 receiving yards, while the next-best Arkansas receiver has 114 yards. Memphis ranks 80th in the nation in defensive EPA/pass, which means this Arkansas offense that ranks eighth in the nation in offensive EPA/pass should have a monster game. Blake will be the main beneficiary of this advantageous matchup, making him an ideal choice for Week 4 DFS lineups.

Blake Krass has contributed to DraftKings since 2024, and is a content creator with a specialty in sports betting. Blake primarily focuses on college football and NFL coverage but will also be covering college basketball, the NBA, MLB and more. Prior to arriving at DK, Blake was a sports betting writer for The Action Network.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and customer (my username is blakekrass) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.