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Man City vs. Napoli prediction, pick for Thursday 9/18/25

Man City vs. Napoli prediction, pick for Thursday 9/18/25

Published:

By: Ciaran Doyle

The UCL league phase continues on Thursday as Man City host Napoli.

Man City are -150 favorites for this one on DraftKings Sportsbook, with a draw available at +295. If you fancy a Napoli upset, the Italian side are +400 on the moneyline. Below is my favorite bet for Thursday’s match.

Man City vs. Napoli Prediction, Pick

For the first time since 2017, Man City and Napoli meet once again in the UEFA Champions League. In all four games between these sides since 2011, both teams have scored.

Napoli are back in the competition for the first time since 2023/24 after winning the Italian league last season. It was just their fourth Serie A title in club history. They are off to yet another good start in Serie A this year, winning all three of their matches while scoring six goals and conceding one. They sit top of the league and now face their biggest test of the new season as they travel to Manchester to take on Man City at the Etihad Stadium.

City struggled in their opening three Premier League matches but seemed to turn a corner in their last game, a 3-0 win against cross-town rival Man United. Despite that, they are eighth in the table after losing two of their first four games. The Italian champions present a tough challenge for the Citizens.

On their day, both of these teams are some of the best in Europe. That’s why in this spot, I will take both sides to get on the scoresheet instead of backing either team.

City have scored eight goals in four Premier League games, and have managed to find the net in three of those. Napoli, of course, have scored in all three of their domestic wins. In their last UCL run, Napoli scored in all eight of their matches. Last year’s European run resulted in Man City scoring in eight of their 10 games.

This game should be back and forth, and I could see it going in any direction. I feel the most confident that both teams will score, as they usually do.

The Pick: Both Teams to Score: Yes (-135)

Ciaran has been an editor for the DraftKings Network team since 2023. He graduated from the University of Arizona before attending Arizona State University for his master’s degree in sports journalism. Ciaran previously covered Phoenix Rising FC for Cronkite News before joining DraftKings. He is passionate about sports betting, and his biggest focus has always been on the NFL and soccer. You can find him on X at @Ciaran_Doyle7.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is ciarandoyle77) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.