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James Cook best prop bets for Bills vs. Dolphins on Thursday 9/18/25

James Cook best prop bets for Bills vs. Dolphins on Thursday 9/18/25

Published:

By: Alex Hunter

The Bills are hosting the Dolphins for Thursday Night Football. On DraftKings Sportsbook, Buffalo is favored by 12.5 points and this game carries a total of 49.5 points.

Below, I have featured my favorite James Cook prop to consider from this contest.


Best James Cook Prop Bets on DraftKings Sportsbook

James Cook O 67.5 Rushing Yards (-113)

After eclipsing 1,000 rushing yards in back-to-back seasons, James Cook inked a four-year, $48 million contract extension with the Bills this offseason and as expected, he has been the team’s primary rusher this season. Cook is averaging 17 carries per game, which is 70.8% of the running back carries for Buffalo and he is producing 5.2 YPC. Plus, Cook ranks fifth in YAC among the running backs that have seen at least 10 carries (136). This past Sunday, the 25-year-old rushed for 132 yards and two touchdowns on 21 carries in the Bills’ 30-10 rout over the Jets.

Buffalo leading for the entirety of that contest translated into the Bills rushing the ball on 60.6% of their plays and it’s safe to expect another rush-heavy attack for Buffalo this Thursday vs. the Dolphins. The Bills are a huge 12.5-point home favorite for this AFC East matchup and Cook should see around 20 carries with Buffalo likely to lead for most of this lopsided affair, putting him in a prime position to clear 67.5 rushing yards.

In the nine games that the Bills have won by double digits the last two seasons, Cook is averaging 83.6 rushing yards per game and he has surpassed 67.5 rushing yards in six of these nine tilts, including a 78-rushing yard performance vs. Miami in Week 2 of last season.

Alex Hunter is an avid DFS player and sports handicapper, who has been a proud member of the DraftKings Network team since 2020. He is a data-driven analyst, who earned his bachelor’s degree in communications at Worcester State University and has been in the sports content business for nearly a decade, covering the NBA, NFL and PGA TOUR. Alex is a diehard Boston Celtics fan, who loves to be on the golf course when he isn’t grinding lineups or producing content. For all of Alex’s work or if you need any lineup advice, be sure to follow him @Hunta512 on X.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is Hunta512) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.