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NFL Best Bets: Top player props for Las Vegas Raiders vs. Los Angeles Chargers for NFL Week 2 on 9/15/25

NFL Best Bets: Top player props for Las Vegas Raiders vs. Los Angeles Chargers for NFL Week 2 on 9/15/25

Updated:

By: Dan Johnson

Two 1-0 teams meet indoors with pace and playmaking on tap. Los Angeles just hung 27 on Kansas City with 394 total yards, while Las Vegas rolled up 389 in Foxborough behind a vertical surge. The market sits at Chargers -3.5 with a total of 46.5, and the matchup profile leans toward sustained passing efficiency. Expect volume to concentrate through reliable chains-movers and explosive intermediates rather than a ground slog. I sure do. Check out how that fits into the prop market for the game by my analysis below.

Here are my favorite player props for this Week 2 NFL game between the Raiders and the Chargers.

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Raiders vs. Chargers Best Prop Bets

Justin Herbert o22.5 completions (-110)

I wrote this up in my preview, pick, & prediction for this game, as well. Los Angeles threw on 57.6% of snaps in Week 1 (34 dropbacks on 59 plays), and Justin Herbert converted at a surgical 73.5% (25 completions) for 9.4 yards per attempt and 318 yards. Indoors, those efficiency levers travel. Las Vegas just faced 46 opponent attempts and allowed a 65.2% completion rate, a signal that volume can clear this threshold without needing extreme pace. The Raiders created nine QB hits and four sacks, pressure that typically compresses average depth of target and funnels play-callers toward high-percentage throws; that pressure profile often lifts completion totals even when aDOT tightens.

Herbert distributed to eight teammates and saw three different receivers at 68+ yards, which spreads conversion probability across multiple options and stabilizes third-down success late. Six of Keenan Allen’s seven grabs were either first downs or touchdowns, and Ladd McConkey added six for 74; that combination of stick-movers plus crossers sustains drive count. Plug a conservative 35–38 attempts into Herbert’s recent accuracy band (68–72% in rhythm games) and you project 24–27 completions as the median range. With Los Angeles favored and live to play from in front, two-minute and four-minute sequences both create short throws that pad completion totals. The number asks for only 24 in a dome after 25 outdoors against a stronger secondary, aligning neatly with an over-leaning game script.

Geno Smith o243.5 total passing yards (-110)

Geno Smith opened with 362 yards on 24-of-34 (70.6%) at 10.6 yards per attempt, including four completions of 20+ yards. Las Vegas posted 6.7 yards per play and 333 through the air in that win, and the structure remains pass-forward if game state tilts negative as a 3.5-point underdog. The opponent allowed 249 passing yards on a 61.5% completion rate to Patrick Mahomes and conceded 347 total yards; indoors, that baseline expands because explosives are less weather-limited and protection communication improves. Smith’s September trendline is favorable (289+ in a majority of recent September starts), and the personnel underscores why: Brock Bowers went five for 103 last week at 20.6 yards per catch, while Jakobi Meyers logged eight for 97. That pairing stretches seams and sideline intermediate windows, which is precisely where Los Angeles was challenged at times despite winning.

The Raiders’ pass protection did allow 4 sacks, but they also generated nine explosive completions (20+ yards) as an offense in Week 1, showing they can cash chunk plays when the pocket holds for 2.5–3.0 seconds. If the Chargers score first again, Las Vegas’ pass rate should climb into the mid-60% range, which, at even a tempered 7.8–8.4 yards per attempt, drives Smith comfortably past the mid-240s on 32–36 attempts. Red-zone efficiency is a bonus; yardage clears before finishing drives even matters. With dome conditions, explosive weaponry healthy enough to threaten levels, and a likely trailing script in portions, the over is the sharper side.

Ladd McConkey o72.5 total receiving yards (-110)

Ladd McConkey’s usage flows cleanly into this matchup: six receptions for 74 yards in Week 1, and a recent run with 74+ in eight of his last nine outings. The distribution footprint is ideal for an over: Los Angeles had three different teammates at 68+ yards, which reduces bracket pressure and forces honest coverage across formations. The opponent just allowed 276 passing yards on 30 completions (65.2%), and even a modest replication of that efficiency yields a strong McConkey path if target share hovers in the high teens. Herbert’s 73.5% completion rate points to on-time intermediate work—deep digs, seams, and crossers—that match McConkey’s strengths, especially against a defense that produced 9 QB hits and 4 sacks last week and may adjust with softer zones to keep explosives capped. That trade-off typically gifts catch-and-run opportunities between 8–18 yards, where McConkey’s route tempo turns first reads into chunk gains.

Indoors, splits tend to push YAC ceilings up a few percentage points due to footing and ball control, and Herbert’s eight-target tree makes it difficult for a single defender to erase any one option. With the total at 46.5 and Los Angeles live for 30%+ of snaps in sustained drive scripts, a 7–9 target projection at 9.5–11.5 yards per target gets McConkey to an 80–96-yard median. Add two-minute opportunity near halves, where Los Angeles likes tempo with layered crossers, and the probability band widens in his favor. This is a correlation-friendly piece with Herbert volume and an over-leaning environment.

Dan Johnson has been an editor, writer, and analyst for DraftKings and DraftKings Network since 2024. He’s previously held editorial posts at The Paris Review, Macmillan Publishers, Bedford/St. Martin’s Press, ASSIGNMENT Magazine, and FantasySixPack. You can find his various editorial work & writing (sports-related and non-) at all of the above.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is thegreatdansby9) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.