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Best Omarion Hampton prop bet for Raiders vs. Chargers NFL Week 2 on Monday 9/15/25

Best Omarion Hampton prop bet for Raiders vs. Chargers NFL Week 2 on Monday 9/15/25

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By: Dan Johnson

We get one of the beloved early-season MNF double-headers tonight, and the latter game is slated to be a heated divisional battle between two offenses that are feeling themselves. We’ve got a ton of MNF coverage already here at DKN (see some links to mine below), but I’m interested in hitting the prop bets for the big players: Ladd McConkey, Ashton Jeanty, Brock Bowers, etc.

As such—below, check out one of my favorite Omarion Hampton props to consider from this late-night tilt.


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Best Omarion Hampton prop bet for Raiders vs. Chargers

Omarion Hampton o56.5 total rushing yards (-115)

Omarion Hampton has already emerged as the Chargers’ three-down bell-cow back in 2025: he played 80% of snaps and accounted for 15 carries and 2 catches in Week 1. Those 15 carries went for 48 yards (3.2 YPC) against Kansas City—modest on the surface—but that KC front ranked top-6 in yards-per-carry allowed (4.1) last season, and Hampton only needs one or two explosive runs to flip the game. He already ran both of LAC’s red-zone rushes and ran a route on 80.6% of passing-down snaps, underscoring how much trust Harbaugh has in him near the goal line. Veteran Najee Harris barely played (one carry, one catch), confirming Hampton’s lead role. He took 15 more total touches than Harris in that opener, a massive gap that makes him the undisputed starter.

At 6’0″, 220 lbs, Hampton is a punishing runner with pro speed—he ran a 4.46 40-yard dash (38″ vertical) at the NFL Combine, and in college he forced 0.41 missed tackles per carry (fourth-best of the 2025 RB class) (90% of those broken tackles were simply running people over). All signs say he’ll churn out chunk yardage against Vegas’s front. The Raiders held New England to just 60 rush yards on 20 tries last week, but rookie Tre Henderson still averaged 5.4 YPC; Vegas allowed 4.4 YPC in 2024.

The Chargers offense, by 2024’s vector, wants to run—the team was 10th in rush yards per game last season and attempted only 30 passes in Week 1—so with Hampton commanding the workload and the favorable matchup, the market has set his rushing line at 56.5 yards (-110 on DK). Plus, Los Angeles is a three-point road favorite, making a ball-control, run-heavy script likely.

Dan Johnson has been an editor, writer, and analyst for DraftKings and DraftKings Network since 2024. He’s previously held editorial posts at The Paris Review, Macmillan Publishers, Bedford/St. Martin’s Press, ASSIGNMENT Magazine, and FantasySixPack. You can find his various editorial work & writing (sports-related and non-) at all of the above.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is thegreatdansby9) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.