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Missouri State Bears vs. SMU Mustangs prediction, pick for CFB Week 3 on Saturday 9/13/25

Missouri State Bears vs. SMU Mustangs prediction, pick for CFB Week 3 on Saturday 9/13/25

Published:

By: Dan Johnson

Springfield hosts history Saturday afternoon as Missouri State plays its first home game since joining the FBS ranks. Robert W. Plaster Stadium should be buzzing, the Bears stepping into the moment with a chance to measure up against playoff-tested opposition. SMU arrives unranked after a double-overtime collapse to Baylor, their first time outside the AP Top 25 since last October. It’s a collision of two programs in very different places: one climbing into the big leagues, the other desperate to keep playoff ambitions alive. The contrast sharpens the edges of this matchup, setting the stage for fireworks in a game where pride, tempo, and resilience collide. Below is my prediction and pick for College Football Week 3’s game between the Missouri State Bears and the SMU Mustangs.

Here’s how I’ll play it. I’ll be pumping out these predictions for individual games all season, with plenty of coverage here on DraftKings Network. Follow my handle @dansby_edits for more betting plays.

Missouri State vs. SMU prediction, preview

SMU walks into Springfield with a get-right mandate and a box score that says the fireworks should travel. Kevin Jennings just diced Baylor for 295 yards and three scores and sits on 555 yards at a blistering 73.1% with five touchdowns through two, while Romello Brinson has detonated downfield for 11 catches, 247 yards, and three touchdowns at 22.5 yards per. Tomarion Harden brings real balance after ripping 19 carries for 115 yards and three touchdowns, and SMU has leaned slightly pass-first but still multiple — 51.1% pass rate / 48.9% run rate with average tempo at 68.5 snaps. The advanced lens says the Mustangs haven’t even hit their ceiling yet — EPA per pass -0.05 and EPA per run -0.05 — but the explosive plays are already there, fueled by a Big-Time Throw % of 4.29%. Jennings will test a Bears secondary that just allowed two explosives of 20+ at Marshall and has shown issues staying clean in coverage despite a middling PFF passing-defense look that pairs with Missouri State’s own passing PFF grade of 64.5.

Missouri State counters with Jacob Clark, who brought the program its first FBS win by torching Marshall for 359 yards and three touchdowns and now sits at 506 yards on 67.3%. He’s comfortable spreading it — Ramone Green Jr. has morphed into a matchup problem from the slot and on wheels (151 receiving yards and a score), and Jmariyae Robinson plus Tristian Gardner have stacked chunk gains on the boundary. The Bears’ profile is pass-centric by design — 61.8% pass rate / 38.2% run rate, 66.5 snaps a game — because the ground game has lagged, but Clark’s rhythm throws and Green’s yards-after-catch can punish space. Missouri State’s risk-reward toggles show up in the metrics: Turnover-Worthy Play % only 3.70% (clean enough to sustain drives) yet the protection leaks, which raises the variance and, in this spot, plays to our ticket.

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SMU vs. Missouri State pick, best bet

This total climbs because both defenses leak in ways that amplify pace. SMU’s stop unit ranks 129th in yards allowed at 476 per game and 110th in scoring defense at 30.5 points per game. The secondary has been the liability, yielding 342 passing yards per game — second-worst in the FBS — and that flaw dovetails with Missouri State’s pass-heavy approach. The Bears have produced 273.5 passing yards per game, 33rd nationally, and that profile guarantees they keep attacking through the air. Clark has taken sacks, but his receivers win downfield, and Missouri State’s willingness to lean 62% pass creates the right tempo to keep landing shots.

On the ground, Missouri State’s defense has been nearly as permissive. The Bears rank 126th against the run at 212 rushing yards allowed per game, and they’ve been gashed at 5.8 yards per attempt. That’s a gift to an SMU ground game that has already posted 157 yards and three touchdowns from Harden. Add the Bears’ inability to finish defensive possessions — 46.5 points allowed per game, 134th nationally — and there’s no profile to slow Lashlee’s scheme. Combine that with SMU’s own offensive rhythm, 429 yards per game and a national rank of 25th in scoring at 43.5 points per game, and the math pushes upward. Each team runs close to 67 snaps, both throw more than they run, and the structural weaknesses line up with each other’s strengths.

Call it SMU 45, Missouri State 20 — I expect SMU’s explosives plus Missouri State’s pass volume to pull this into the mid-60s by the fourth. I believe Clark and the shiny new FBS-darling Bears could cover the four-spot of touchdowns here, too. I just like the lean on points better than the cover by the dog. Just in case SMU gets wacky. In any case, I think Springfield’s about to see a show.

Best bet: Missouri State vs. SMU o60.5 total points (-110)

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Dan Johnson has been an editor, writer, and analyst for DraftKings and DraftKings Network since 2024. He’s previously held editorial posts at The Paris Review, Macmillan Publishers, Bedford/St. Martin’s Press, ASSIGNMENT Magazine, and FantasySixPack. You can find his various editorial work & writing (sports-related and non-) at all of the above.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is thegreatdansby9) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.