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Best Brock Purdy prop bets for Seahawks vs. 49ers on Sunday, 9/7/25

Best Brock Purdy prop bets for Seahawks vs. 49ers on Sunday, 9/7/25

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By: Charlie Cummings

At last, we get to sit down and enjoy a full NFL Sunday. There are excellent matchups across the board, including an NFC West matchup to get the season started with a bang. The San Francisco 49ers will travel to Seattle to take on the Seahawks, with franchise quarterback Brock Purdy looking for revenge.

San Francisco is a -122 favorite on the moneyline on DraftKings Sportsbook. The total is set at 43.5 points. Let’s dig into my favorite Brock Purdy player prop for this showdown in Seattle.

Best Brock Purdy Prop Bets on DraftKings Sportsbook

Last season was a weird one for the 49ers. As injuries piled up and key players took a step back, a promising NFC contender came apart at the seams. Despite that, Brock Purdy took a noticeable step forward in all facets of the game. He continued one of his favorite hobbies as well: dismantling the Seahawks.

Their Week 11 loss on a last-minute Geno Smith scramble touchdown was the first loss of Purdy’s career against their bitter rivals. It was also Brock’s second straight productive game with his legs, marking a year where his scrambling took a giant leap. After rushing for 19 yards in the first matchup, Purdy wheeled for 40 yards and a score in the second game. In fact, Purdy rushed for double-digit yards in 13 of his 15 starts last season.

San Francisco will lean heavily on its running game, even with Christian McCaffrey a tad hobbled in practice. And with heavy running comes play-action bootlegs in the Kyle Shanahan offense. With San Francisco’s receiving core looking worse for wear, there will be several instances where Purdy takes his drop-back and finds everybody blanketed. That’s when Mr. Relevant will go to work with his legs to pick up yardage.

Best Bet: Brock Purdy 15+ Yards Rushing +110

I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.