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San Francisco Giants vs. Colorado Rockies prediction, pick for Wednesday 9/3/25

San Francisco Giants vs. Colorado Rockies prediction, pick for Wednesday 9/3/25

Published:

By: Charlie Cummings

Stop me if you’ve heard this before: the San Francisco Giants are getting in the playoff race while the Colorado Rockies are losing 100 games. Crazy, right? Colorado lost their 100th game of the season last night against San Francisco in dramatic fashion, to say the least.

The Giants enter as -207 moneyline favorites on DraftKings Sportsbook. The over/under is set at 11 runs. Letโ€™s dig into a preview, prediction, and best bet for this Giants vs. Rockies matchup.


Giants vs. Rockies prediction, preview

When playing in Coors Field during hot weather, the pitchers are of paramount importance.

San Francisco’s second ace, Robbie Ray, picked a tricky time to make a start at Coors Field. He’s given up 3+ earned runs in three of his last four starts; that had only happened six times in 24 previous starts. He’s issuing more walks than usual over that stretch and giving up hard contact, an unfavorable equation for a start at elevation. With the Giants chasing down hope of a Wild Card berth, they’ll need Ray to hold down the fort in order to gain a game on the Mets.

His opposite number, Germรกn Mรกrquez, is not having the same kind of year. According to Baseball Savant, his pitching has cost the Rockies 32 total runs this year. That’s a 1st percentile mark in all of the MLB. He’s in the habit of getting shelled; in his only start against the Giants this season, Mรกrquez gave up a pair of homers and five total runs in 4.1 innings. And that was a road game.

What’s worse for Mรกrquez is that this Giants offense is red-hot. They’ve hit 32 home runs in their last 16 games, socking a dinger in each of those games, getting close to a franchise record. It’s a bad time to be facing these Giants, and they’ll go home with a series sweep after today with a big offensive performance.

Best Bet: San Francisco Giants Over 6.5 Total Runs (-115)

I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.