The US Open continues on Sunday as the Round of 16 begins. There are some great matches on Sunday, headlined by Carlos Alcaraz, Novak Djokovic and Taylor Fritz.
These are my US Open best bets to target on DraftKings Sportsbook for the Round of 16 at the US Open.
US Open Round of 16 Best Bets
Carlos Alcaraz vs. Arthur Rinderknech: Alcaraz to win 3:1 (+270)
Carlos Alcaraz has stolen headlines with his new haircut for the US Open, but his play has also been sensational at this tournament. Alcaraz has won each of his three matches in straight sets, looking like a man on a mission. He already has a French Open to his name this season and made the Wimbledon Final. He is a former champion at the US Open and seems on a collision course for a third straight Grand Slam final against Jannik Sinner. However, Arthur Rinderknech could present a bit of a challenge to Alcaraz. Alcaraz is 3-0 in his career against Rinderknech, but it has never been easy. They played a four-set match at the 2021 US Open, had a third set that required a tiebreaker at the Queen’s Club in 2024, then Rinderknech won nine games in two sets against Alcaraz at the Queen’s Club in 2025. Rinderknech upset a top-20 player, Alejandro Davidovich Fokina, earlier in this tournament and should be able to steal one set off Carlos Alcaraz.
Novak Djokovic vs. Jan-Lennard Struff: Djokovic to win 3:0 (+105)
Novak Djokovic has looked like his old self so far at the US Open. There are rumors that this could be the final major for the most decorated player in men’s tennis history, Novak Djokovic. Whether that is the case or not, Djokovic is desperate for one more major title before he leaves the sport. He has struggled to take down the likes of Jannik Sinner and Carlos Alcaraz over the past couple of seasons, but against inferior competition, he has been dominant. He required four sets in each of his past two matches, but he dominated the sets that he did win. Djokovic is 7-0 in his career against Jan-Lennard Struff, and they have been dominant wins. In 17 career sets against each other, Djokovic has won 16 of them. He should take down Struff in straight sets once again in this match.
Taylor Fritz vs. Tomas Machac: Parlay- Fritz to win & Machac to win at least one set (+104)
Taylor Fritz is on a mission to be the first American man to win a Grand Slam title since 2003. He was a US Open finalist last year and is looking to take things one step further this year. He has played well so far at this US Open, but has a tough matchup against Tomas Machac in the Round of 16. Fritz is 2-0 in his career against Machac, playing a five-set thriller at Roland Garros in 2020, and Machac was forced to retire in the third set at the United Cup earlier this year. History should repeat itself in this match, with Fritz winning but Machac putting up a good fight and winning at least one set. Machac has been great so far at the US Open, winning each of his first three matches in straight sets. Fritz’s talent should get him the win at the end of the match, but Machac should find a way to steal at least one set.
