The 2025 MLB season is heading down the final stretch. There are far more ways to get involved in the action than just via traditional betting. One of the more unique features on DraftKings this year is Pick6 Fantasy Baseball!
Here are my top Pick6 plays for today’s MLB slate.
Nick Castellanos More Than 0.5 Home Runs
There is something about Braves pitcher Bryce Elder that makes Nick Castellanos want to drive a ball to deep left field. Castellanos has fascinating career numbers against Elder. In eight career plate appearances against Elder, Castellanos has four hits, all of which have been home runs. The Phillies exploded for 19 runs last night against the Braves and are looking to take out some anger after getting swept by the Mets in a series where they could have effectively ended the NL East race. Elder has really struggled this season, with a 6.12 ERA on the year. When Elder faced the Phillies earlier this year, Castellanos hit a home run, and the Phillies won the game 13-0, with Elder getting charged for nine of those runs. Castellanos and the Phillies should take it to Elder again, making the value on this pick worth a shot.

Yordan Alvarez More Than 1.5 Total Bases
Yordan Alvarez finally returned to the Astros’ lineup after missing months of action. Alvarez has been one of the best hitters in baseball over the past few years and has been sorely missed by Houston this summer. He has only come to the plate nine times since returning from injury, but he showed that he is ready to contribute right away by hitting a home run on Wednesday night against the Rockies. Alvarez will be excited to face Tyler Anderson in the first game of this series against the Angels. He has a .381 batting average with three home runs in 21 career at-bats against Anderson. Alvarez should be fresh for tonight’s game and generate an extra-base hit against an opponent he has dominated over the years.

Isiah Kiner-Falefa Less Than 0.5 Singles
Isiah Kiner-Falefa is having a decent first full season in Pittsburgh, relative to his career numbers. However, his .641 OPS would make this the second-worst season of his career, using only that metric. A big reason for that is his massive struggles against left-handed pitching this season. Against righties, Kiner-Falefa has a .680 OPS and a .280 batting average. However, against lefties, he has a .521 OPS and a .229 batting average. Kiner-Falefa should struggle tonight against Red Sox rookie Payton Tolle. Tolle is making his first career start, but is the top prospect in the Red Sox organization and the No. 28 prospect in all baseball. Tolle has been dominant in the minor leagues and should hit the ground running against the worst lineup in baseball.

What is DraftKings Pick6?
Pick6 is a peer-to-peer fantasy variant where you build a lineup (your “Pick Set”) of 2+ players and select whether or not you believe each will outperform their listed stat projection. Enter your Pick Set in Pick6 contests to compete against other users. Get enough picks correct and win a share of cash prizes.
How to Play
Create a Pick Set
Create a Pick Set by choosing 2+ players from the same sport and Pick Group (a set of picks available from a group of set competitions). For each player, simply select if you think they’ll have more or less than their listed stat projection. In each Pick Set, you can not pick the same player twice, and you must pick players from at least two different teams.
Enter an Amount
Once you finalize your Pick Set, choose your entry fee amount. Your entries will be automatically distributed into available contests, subject to your confirmation.
Sweat Your Picks
When the games go live, use the My Picks tab to follow your picks in real time to track how your players are performing against their projections and how they stack up against other users.
Compete for Prizes
Make enough correct picks and win a share of the contests’ guaranteed prizes. Any prizes won will be credited to your DraftKings account after contests are finalized.
Play at DraftKings Pick6 or by downloading the DraftKings Pick6 app on Apple or Google!
Gambling Problem? Call 1-800-GAMBLER. Must be at least 18 years or older. Higher age limits may apply in some states. Eligibility restrictions apply. Valid only in states where DraftKings Pick6 operates. Void where prohibited. For entertainment purposes only. Winning a contest on DraftKings depends on knowledge and exercise of skill. See terms at pick6.draftkings.com.