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DraftKings MLB Pick6 Fantasy Baseball Picks: Top Picks for Friday 8/22/25

DraftKings MLB Pick6 Fantasy Baseball Picks: Top Picks for Friday 8/22/25

Published:

By: Blake Krass

The 2025 MLB season is heading down the final stretch. There are far more ways to get involved in the action than just via traditional betting. One of the more unique features on DraftKings this year is Pick6 Fantasy Baseball!

Here are my top Pick6 plays for today’s MLB slate.


Trevor Story More Than 1.5 Total Bases

The Red Sox and Yankees played a thriller at Yankee Stadium on Thursday night as the two teams continue to battle for playoff positioning. Trevor Story played a big role in the win and hopes to contribute even more in Friday night’s matchup. Story will be facing off against the left-handed Max Fried to start the game. Story has been great against lefties this season, sporting a .280 batting average and a .766 OPS against lefties this season. Fried has struggled throughout his career against Story. Trevor Story is 4/10 with two home runs against Fried in his career. Fried has really struggled as of late, with a 7.00 ERA over his past five starts. Story should take advantage of the circumstances and produce an extra-base hit to get over this number.


Michael Harris II More Than 1.5 Hits + Runs + RBIs

Michael Harris II is one of the hottest hitters in baseball at the moment. The Braves are surging as a team, having won eight of their past ten games. It might be too little too late for a playoff push for Atlanta, but in a huge series against the Mets, they will do their best to keep the hot streak going. Harris has been having the worst season of his career at the plate, but he finally found something over the past couple of weeks. Over the past 14 days, he has been batting .444 with a 1.296 OPS. Harris has six home runs in his past 12 games, after only hitting ten in the previous 113 games. Harris has also been much better against righties this season, with a .719 OPS against right-handers. Mets rookie Nolan McLean has only made one career start. He pitched great in that game, but on the road against a hot Atlanta lineup will be a much tougher task than his first start, which was at home. Harris should get at least one hit in this game and be able to generate a run to get over this number.


Luis Arraez More Than 0.5 Singles

Luis Arraez has been one of the best contact hitters in baseball over the past few years. He has become a somewhat controversial figure in recent years, as the importance of advanced metrics has devalued contact hitters like Arraez. However, as the great Billy Beane once said, he gets on base. Arraez is actually having a poor year by his standards, but that means batting .287. However, he will feel confident in tonight’s matchup against Blake Snell. Arraez is 6/9 in his career against Snell, with five of those six hits being singles. Arraez has not hit a home run or a triple since July 28th. He has no power at the plate, but should be able to drive a base hit against Snell.


What is DraftKings Pick6?

Pick6 is a peer-to-peer fantasy variant where you build a lineup (your “Pick Set”) of 2+ players and select whether or not you believe each will outperform their listed stat projection. Enter your Pick Set in Pick6 contests to compete against other users. Get enough picks correct and win a share of cash prizes.

How to Play

Create a Pick Set

Create a Pick Set by choosing 2+ players from the same sport and Pick Group (a set of picks available from a group of set competitions). For each player, simply select if you think they’ll have more or less than their listed stat projection. In each Pick Set, you can not pick the same player twice, and you must pick players from at least two different teams.

Enter an Amount

Once you finalize your Pick Set, choose your entry fee amount. Your entries will be automatically distributed into available contests, subject to your confirmation.

Sweat Your Picks

When the games go live, use the My Picks tab to follow your picks in real time to track how your players are performing against their projections and how they stack up against other users.

Compete for Prizes

Make enough correct picks and win a share of the contests’ guaranteed prizes. Any prizes won will be credited to your DraftKings account after contests are finalized.


Play at DraftKings Pick6 or by downloading the DraftKings Pick6 app on Apple or Google!


Gambling Problem? Call 1-800-GAMBLER. Must be at least 18 years or older. Higher age limits may apply in some states. Eligibility restrictions apply. Valid only in states where DraftKings Pick6 operates. Void where prohibited. For entertainment purposes only. Winning a contest on DraftKings depends on knowledge and exercise of skill. See terms at pick6.draftkings.com.


Blake Krass has contributed to DraftKings since 2024, and is a content creator with a specialty in sports betting. Blake primarily focuses on college football and NFL coverage but will also be covering college basketball, the NBA, MLB and more. Prior to arriving at DK, Blake was a sports betting writer for The Action Network.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and customer (my username is blakekrass) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.