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DraftKings MLB Pick6 Fantasy Baseball Picks: Top Picks for Saturday 8/16/25

DraftKings MLB Pick6 Fantasy Baseball Picks: Top Picks for Saturday 8/16/25

Published:

By: Blake Krass

The 2025 MLB season is heading down the final stretch. There are far more ways to get involved in the action than just via traditional betting. One of the more unique features on DraftKings this year is Pick6 Fantasy Baseball!

Here are my top Pick6 plays for today’s MLB slate.


Shohei Ohtani More Than 0.5 Home Runs

Shohei Ohtani is having another monster season at the plate. He ranks second in the MLB in OPS, second in home runs, fourth in WAR and is in a two-way battle for the NL MVP. He leads the MLB in total bases and runs scored as well, and he will look to keep that rolling tonight against the Padres. Dylan Cease will be on the mound for San Diego, a pitcher that Ohtani has dominated throughout his career. In 25 career at-bats against Cease, Ohtani has a .360 batting average and has hit three home runs. Ohtani has hit five home runs in his past eight games and has a great chance to keep that run of form going against Cease. The Dodgers put up six runs the last time they faced Cease and will look to do that again tonight.


Brent Rooker More Than 1.5 Hits + Runs + RBIs

Brent Rooker has been one of the most underrated hitters in baseball over the past couple of seasons due to playing for the Athletics. However, he has consistently been one of the best hitters in baseball over the past three seasons. Since 2023, he ranks seventh in the MLB in wRC+. Rooker has 16 hits + runs + RBIs over his last six games, an average of 2.67 per game. He has a great chance to keep things going against Tyler Anderson and the Angels. Rooker has crushed lefties this season, with a .330 batting average and a 1.017 OPS against lefties this season. Specifically against Anderson, Rooker has a .357 career batting average, including two home runs in 14 career at-bats. Rooker has a great chance to crush Anderson and get over this number.


Juan Soto More Than 1.5 Hits + Runs + RBIs

Juan Soto and the Mets have been on a miserable run over the past few weeks. However, as of late, the pitching has been the major issue for New York. The Mets have averaged 6.8 runs over their past six games, but they are 1-5 over that stretch. Soto has not put up the MVP-level numbers that many hoped for in his first season with the Mets. However, by normal standards, he is having another excellent season. He ranks third in the MLB in runs scored, seventh in home runs, ninth in WAR and 12th in OPS. He has been even stronger against righties, with a .961 OPS against right-handed pitching this season. Soto is 2-of-5 with a home run and a double in his career against Bryan Woo. While the Mets’ pitching continues to struggle, the Mets’ bats should keep the positive momentum, and Soto can get over this number.


What is DraftKings Pick6?

Pick6 is a peer-to-peer fantasy variant where you build a lineup (your “Pick Set”) of 2+ players and select whether you believe each will outperform their listed stat projection. Enter your Pick Set in Pick6 contests to compete against other users. Get enough picks correct and win a share of cash prizes.

How to Play

Create a Pick Set

Create a Pick Set by choosing 2+ players from the same sport and Pick Group (a set of picks available from a group of set competitions). For each player, simply select if you think they’ll have more or less than their listed stat projection. In each Pick Set, you can not pick the same player twice, and you must pick players from at least two different teams.

Enter an Amount

Once you finalize your Pick Set, choose your entry fee amount. Your entries will be automatically distributed into available contests, subject to your confirmation.

Sweat Your Picks

When the games go live, use the My Picks tab to follow your picks in real time to track how your players are performing against their projections and how they stack up against other users.

Compete for Prizes

Make enough correct picks and win a share of the contests’ guaranteed prizes. Any prizes won will be credited to your DraftKings account after contests are finalized.


Play at DraftKings Pick6 or by downloading the DraftKings Pick6 app on Apple or Google!

Blake Krass has contributed to DraftKings since 2024, and is a content creator with a specialty in sports betting. Blake primarily focuses on college football and NFL coverage but will also be covering college basketball, the NBA, MLB and more. Prior to arriving at DK, Blake was a sports betting writer for The Action Network.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and customer (my username is blakekrass) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.