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San Francisco Giants vs. Miami Marlins prediction, pick for Wednesday 6/25/25

San Francisco Giants vs. Miami Marlins prediction, pick for Wednesday 6/25/25

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By: Keagan Smith

The San Francisco Giants lost a 4-2 battle against the Miami Marlins at Oracle Park last night, but Wednesday provides a chance to shake off the loss and get back in the win column as these teams run it back again. It’s the final game on tonight’s slate, so settle in for some late-night action on the diamonds with the 9:45 p.m. EST start.

Here’s a Giants vs. Marlins prediction and pick on DraftKings Sportsbook for Wednesday.

Giants vs. Marlins prediction, preview

San Francisco Giants

The Giants are 44-35 on the season at second in the NL West with a solid 25-15 record at their home park. They may be 4-6 over their last 10 games, but the team is still working to integrate Rafael Devers into the lineup after they traded for the former Red Sox star just last week. Once he gets going, it’s wheels up for this squad moving forward.

San Francisco ranks 17th in AVG and runs scored but 11th in OPS over the last 15 days. They’re a bit shaky at the moment and the offense has been pretty hit-or-miss overall this season, but the Giants clearly have the pieces to contend with Devers, Heliot Ramos, Matt Chapman and a handful of other talented batters. Plus, their pitching staff ranks second in ERA, 11th in WHIP and 12th in strikeouts.

Miami Marlins

The Marlins aren’t having the same caliber of campaign with a 32-45 record overall, good for fourth in the NL East. It’s a tough scene for Miami as they’ve still failed to recapture the magic of a successful 2023 season in which they made the playoffs, but hope remains that eventually the team can build to sustainable success.

The Marlins are actually better on offense than one might expect, ranking 11th in AVG and 19th in OPS this year. Consistent scoring remains a concern at 24th in runs though, and with a pitching staff that falls bottom-six in ERA and WHIP, they don’t have a ton of arm talent to make up for it. The Giants’ can capitalize on that tonight if the bats wake back up.

Giants vs. Marlins pick, best bet

The Giants are strong favorites this evening with -232 Moneyline odds on DraftKings Sportsbook to the Marlins’ Moneyline odds of +187. The run total of 6.5 marks the lowest remaining line on the slate.

Right-handed ace Logan Webb takes the mound for San Francisco with the upper hand tonight. In 101.1 innings, he’s thrown to the tune of a 2.49 ERA, 1.12 WHIP and 114 strikeouts — those numbers improve to 2.35 and 1.07 across his last seven games.

Miami starts righty Edward Cabrera, who hasn’t quite recaptured the form of his excellent 2022 campaign. This season, he’s logged a 3.81 ERA and 1.39 WHIP with 63 strikeouts in 59.0 innings. The numbers are respectable, but going blow-for-blow against Webb presents a very tall task.

For tonight’s top betting pick, I like Marlins +1.5 quite a bit at -120 odds on DKSB. It might be a somewhat bold pick given the perceived gap between these teams, but Devers is still adjusting to life in San Francisco and hasn’t really found his stride yet with the team. Plus, Cabrera’s numbers are sneaky-good over his last seven outings with a 2.08 ERA, 1.18 WHIP and 39 punchouts in 34.2 innings. I think he can limit the Giants enough to keep things competitive for Miami in this one.

Best bet: MIA Marlins +1.5 (-120)

Click the odds on this bet to tail!

Keagan is a Texas-based editor and analyst who believes sports are the true eighth wonder of the world. After starting out in local media, he’s provided coverage for DraftKings Network since 2024. He gravitates toward football, hoops and hockey, but is happy to watch and write about any game that involves a ball or a puck. While his own athletic career ended in middle school, he’s also an avid fantasy player with a soft spot for dynasty formats, spending countless hours crafting the ever-elusive perfect squad.
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I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.