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DraftKings MLB Pick6 Fantasy Baseball Picks: Top Picks for Saturday 6/21/25

DraftKings MLB Pick6 Fantasy Baseball Picks: Top Picks for Saturday 6/21/25

Published:

By: Blake Krass

The 2025 MLB season is heating up. There are far more ways to get involved in the action than just via traditional betting. One of the more unique features on DraftKings this year is Pick6 Fantasy Baseball!

Here are my top Pick6 plays for today’s MLB slate.


Rafael Devers More Than 0.5 Hits (Promo Pick)

Rafael Devers is making his second appearance against his former team just days after being traded out of Boston. Devers went 0-for-5 in his first game against his former team and will be looking for redemption in the second game of this series. This promo pick allows Pick6 customers to get Devers to register a hit at 1x instead of 0.7x. Devers has an .885 OPS this season and should bounce back and at the very least get a hit in the second game against his former team.


Spencer Steer More Than 0.5 Home Runs

Spencer Steer had a slow start to the 2025 season but has started to find his groove in recent days. Steer has been a solid power bat for the Reds over the past two years, hitting 20 or more home runs and 86 or more RBIs in each of the past two seasons. He was struggling to find his power to start this season but has now hit a home run in two of his past six games. Steer has also had great success against Sonny Gray, today’s starter for the Cardinals, in the past. In seven career at-bats against Gray, Spencer Steer has two home runs. He should feel confident at the plate against Gray and have a chance to launch one out of Busch Stadium.


Josh Naylor More Than 1.5 Total Bases

Josh Naylor is having a good first season in Arizona after making his first-ever All-Star Game in 2024. He has an .822 OPS and a 128 OPS+, both better marks than he had in his All-Star season last year. Naylor has been particularly hot in the past two weeks, slashing .367/.407/.958 in his past 12 games. He has 10 RBIs over that same stretch and is a big part of a formidable Diamondbacks offense. Carson Palmquist is on the mound in Colorado tonight. Palmquist has struggled through his rookie season so far, sporting a 7.76 ERA heading into this game. Left-handed batters in particular have feasted on Palmquist. He is allowing a 124 tOPS+ against left-handed batters this season. Naylor should keep his hot streak going and register an extra-base hit in this game.


Ronald Acuna Jr. More Than 1.5 Total Bases

Ronald Acuna Jr. has gotten back to the peak of his powers. After tearing his ACL and missing most of 2024, he then missed the start of 2025 as well. Acuna announced his return with two home runs in his first two games of the season and has not slowed down since. He has not seen enough plate appearances to be a “qualified hitter” when looking at the MLB batting leaders. However, among batters with at least 100 plate appearances, Acuna leads the MLB in batting average, OBP and wOBA. He also ranks second in slugging percentage, OPS and wRC+ behind only Aaron Judge in all of those categories. Despite missing a chunk of the season, Acuna will still be an NL MVP candidate if he sustains this level of production. Not only has Acuna not slowed down, but he has gotten better in the past two weeks. He has a .450 batting average over his past 12 games and should register more than 1.5 total bases today.


Ryan O’Hearn More Than 1.5 Hits + Runs + RBIs

Ryan O’Hearn is having a great season for the Orioles, batting .304 with an .867 OPS. Despite being on a team with so many young stars, O’Hearn leads the team in OPS, slugging percentage and batting average. O’Hearn will be excited to face Clarke Schmidt today at Yankee Stadium. O’Hearn has been fantastic against right-handed batters this season with a .318 batting average and a .924 OPS. He also has a great career history against Schmidt, specifically, batting .417 in 12 career at-bats against Schmidt. Schmidt has struggled against lefties this season, allowing a 133 tOPS+ to left-handed batters. O’Hearn should be able to get on base and generate runs in this game.


Cal Raleigh More Than 0.5 Runs Batted In

Cal Raleigh is having an incredible season in Seattle. Raleigh has been a great player for the Mariners over the past couple of seasons but has now emerged as one of the top hitters in all of baseball. He is currently the MLB leader in home runs and ranks third in RBIs. He ranks second in slugging percentage behind only Aaron Judge and is a legitimate AL MVP candidate. Raleigh has been great all season but is riding a particularly hot bat at the moment. In his past 28 games, he is batting .303 with a 1.145 OPS. That OPS has been even better in the past week, sitting at 1.375 through his past six games. He just went 3-for-4 with two home runs in the first game of this Cubs series and will look to keep that momentum going on Saturday.


What is DraftKings Pick6?

Pick6 is a peer-to-peer fantasy variant where you build a lineup (your “Pick Set”) of two or more players and select whether you believe each will outperform their listed stat projection. Enter your Pick Set in Pick6 contests to compete against other users. Get enough picks correct and win a share of cash prizes.


How to Play DraftKings Pick6

Create a Pick Set

Create a Pick Set by choosing two or more players from the same sport and Pick Group (a set of picks available from a group of set competitions). For each player, simply select if you think they’ll have more or less than their listed stat projection. In each Pick Set, you cannot pick the same player twice and you must pick players from at least two different teams.

Enter an Amount

Once you finalize your Pick Set, choose your entry fee amount. Your entries will be automatically distributed into available contests, subject to your confirmation.

Sweat Your Picks

When the games go live, use the My Picks tab to follow your picks in real time to track how your players are performing against their projections and how they stack up against other users.

Compete for Prizes

Make enough correct picks and win a share of the contests’ guaranteed prizes. Any prizes won will be credited to your DraftKings account after contests are finalized.


Play at DraftKings Pick6 or by downloading the DraftKings Pick6 app on Apple or Google!


Blake Krass has contributed to DraftKings since 2024, and is a content creator with a specialty in sports betting. Blake primarily focuses on college football and NFL coverage but will also be covering college basketball, the NBA, MLB and more. Prior to arriving at DK, Blake was a sports betting writer for The Action Network.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and customer (my username is blakekrass) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.