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DraftKings MLB Pick6 Fantasy Baseball Picks: Top Picks for Thursday 5/29/25

DraftKings MLB Pick6 Fantasy Baseball Picks: Top Picks for Thursday 5/29/25

Published:

By: Blake Krass

The 2025 MLB season is heating up. There are far more ways to get involved in the action than just via traditional betting. One of the more unique features on DraftKings this year is Pick6 Fantasy Baseball!

Here are my top Pick6 plays for today’s MLB slate.


Matt Olson More Than 0.5 RBIs (Game 1)

Matt Olson is having another strong season in Atlanta. He has consistently been one of the best hitters in baseball over the past few years, and his numbers have been solid so far this season. Over the past two weeks, Olson is batting .286 and has eight RBIs in ten games played. Olson has been working the long ball this season, with 12 home runs so far, he ranks 15th in baseball in homers hit. Olson will be facing off against Cristopher Sanchez in the first game of today’s doubleheader. Olson is 4/12 with two home runs in his career against Sanchez. Between his recent power form and his career power numbers against Sanchez, he should be able to drive in another run in today’s game.


James Wood More Than 0.5 RBIs

The young Nationals outfielder, James Wood, has been a revelation for Washington so far this season. He has a .287 batting average, 15 home runs and 40 RBIs. Wood has a .950 OPS this season, the eighth-best in all of baseball. He has been even better over the last couple of weeks. In the last 15 days, he has been the fourth-best hitter in baseball, measured by fantasy points. Over that stretch, he has 15 RBIs in 11 games and is batting .341. He should keep that hot streak going tonight against Seattle and drive in another run. He is facing the right-handed Emerson Hancock, who has struggled significantly this season. He has an ERA of 5.95 and has struggled even worse against left-handers, allowing a tOPS+ of 114 against lefties. Wood should be able to drive in a run off of Hancock in this game.


Jose Berrios Less Than 5.5 Hits Against

Jose Berrios had a terrible first start of the season, and one or two other blips along the way, which have hurt his season-long ERA. However, over his past few starts, Berrios has been quite dependable for the Blue Jays. In four of his past six starts, he has given up two runs or fewer and gone at least six innings. Tonight, he takes on the Athletics in Toronto and looks to turn in another solid performance. Berrios has allowed five or fewer hits in seven of his past ten starts. He should keep that going tonight and stay under this number.


Ronald Acuna Jr. More Than 8.5 Batter Fantasy Points (Game 2)

Ronald Acuna Jr. has been on fire since making his return to the diamond over the past week. Acuna missed most of the 2024 season and the start of the 2025 season with a torn ACL. Incredibly, Acuna hit a home run on the very first pitch that he faced in his first game back since the injury. He followed that up by hitting another home run in his second game back. He has at least one hit in each of the four games he has played since returning and seems to be back at the top of the game right away. In the second game of tonight’s doubleheader, Acuna is facing Zack Wheeler to start. Wheeler has been one of baseball’s best pitchers over the past few years, but Acuna has held his own against Wheeler in the past. He has four career home runs off Wheeler and should be able to generate some power off of him in this game. If Acuna can hit an extra-base hit and drive in a run, he should get himself over this number.


Brandon Lowe More Than 1.5 Hits + Runs + RBIs

Brandon Lowe has been one of the hottest hitters in baseball over the past several weeks. He has been the fifth-best hitter in standard fantasy baseball scoring over the past two weeks. Over the past 14 days, he is batting .375 with an OPS of 1.224. He has six home runs and 10 RBIs in 12 games started over that stretch. Lowe will be facing off against rookie pitcher Ryan Gusto in Houston tonight. Gusto will be making just his seventh-career start in this game, and he has only survived five or more innings in two of those six starts. Gusto has struggled mightily against left-handed hitters so far this season, allowing opposing lefties a tOPS+ of 140 this season. Lowe should be able to get on base, drive in a run and score one himself in this game against Houston.


Vladimir Guerrero Jr. More Than 1.5 Total Bases

Vladimir Guerrero Jr. is one of the best power hitters in baseball, and he is on pace for another great season in 2025. Guerrero greatly improved his discipline at the plate last season, batting a career-high of .323. He is not only a power threat, but he has also done a good job of hitting for contact this season again, batting .279. Tonight, Guerrero faces off against Jacob Lopez and the Athletics. Guerrero should fare well against the left-handed Lopez. Guerrero has a 137 tOPS+ against left-handed pitching this season. Lopez has only started two games this season, and in one of those, he only made it 2.2 innings. Guerrero should be able to get a hit off Lopez. Even if he can’t, the Athletics have the third-worst bullpen in baseball, with an ERA over 6.00.


What is DraftKings Pick6?

Pick6 is a peer-to-peer fantasy variant where you build a lineup (your “Pick Set”) of two or more players and select whether you believe each will outperform their listed stat projection. Enter your Pick Set in Pick6 contests to compete against other users. Get enough picks correct and win a share of cash prizes.


How to Play DraftKings Pick6

Create a Pick Set

Create a Pick Set by choosing two or more players from the same sport and Pick Group (a set of picks available from a group of set competitions). For each player, simply select if you think they’ll have more or less than their listed stat projection. In each Pick Set, you cannot pick the same player twice and you must pick players from at least two different teams.

Enter an Amount

Once you finalize your Pick Set, choose your entry fee amount. Your entries will be automatically distributed into available contests, subject to your confirmation.

Sweat Your Picks

When the games go live, use the My Picks tab to follow your picks in real time to track how your players are performing against their projections and how they stack up against other users.

Compete for Prizes

Make enough correct picks and win a share of the contests’ guaranteed prizes. Any prizes won will be credited to your DraftKings account after contests are finalized.


Play at DraftKings Pick6 or by downloading the DraftKings Pick6 app on Apple or Google!


Blake Krass has contributed to DraftKings since 2024, and is a content creator with a specialty in sports betting. Blake primarily focuses on college football and NFL coverage but will also be covering college basketball, the NBA, MLB and more. Prior to arriving at DK, Blake was a sports betting writer for The Action Network.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and customer (my username is blakekrass) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.