The Indianapolis Colts are in a difficult position headed into the 2025 season, with questions at the game’s most important position. While most teams around the league either have a quarterback locked in or made steps in that direction during the offseason, Indianapolis is relying on a combination of Anthony Richardson, who has been poor in his first two seasons, and free agency acquisition Daniel Jones, who didn’t even complete the second season of his four-year, $160 million extension with the New York Giants, with sixth-round pick Riley Leonard as an emergency option.
At least they’ll have a new big target to help their quarterback out: former Penn State tight end Tyler Warren, who they drafted with the 14th overall pick in last month’s NFL Draft. Warren finished seventh in Heisman Trophy voting in his senior season with the Nittany Lions and should be ready to contribute from Day One.
Below, you’ll find Indianapolis’ full schedule for the upcoming 2025 season with spreads for each week provided by the DraftKings Sportsbook.
All lines for the 2025 NFL season can be found on DraftKings Sportsbook.
2025 Indianapolis Colts Odds
2025 Indianapolis Colts Schedule
We’ll update each of these games with odds and lines as they become available on DraftKings Sportsbook.
Week 1: Colts (-1.5) vs. Dolphins
Week 2: Colts (+3.5) vs. Broncos
Week 3: Colts (+1.5) at Titans
Week 4: Colts (+6.5) at Rams
Week 5: Colts (-1.5) vs. Raiders
Week 6: Colts (+1.5) vs. Cardinals
Week 7: Colts (+6) at Chargers
Week 8: Colts (-3.5) vs. Titans
Week 9: Colts (+3.5) at Steelers
Week 10: Colts (+1.5) vs. Falcons
Week 11: BYE
Week 12: Colts (+9.5) at Chiefs
Week 13: Colts (+1.5) vs. Texans
Week 14: Colts (+3) at Jaguars
Week 15: Colts (+3.5) at Seahawks
Week 16: Colts (+3) vs. 49ers
Week 17: Colts (-1.5) vs. Jaguars
Week 18: Colts (+4.5) at Texans
