Here we go again with the Buffalo Bills.
After yet another heartbreaking defeat at the hands of Patrick Mahomes and the Chiefs in the postseason, Josh Allen and friends are back at it in 2025. While it would be understandable to feel a certain level of desensitization towards the Bills at this point in their run of recent relevancy, it’s worth noting that Buffalo is currently the favorite to win the AFC on the DraftKings Sportsbook, tied with the Ravens at +350 odds.
Could a trip to the Super Bowl finally be in the cards for the Bills? It certainly helps that both the Jets and Dolphins seem to have taken major steps back in the offseason. The AFC East will likely be a cakewalk for Buffalo and that could be key in locking up a first-round bye.
Below, you’ll find the Bills’ full schedule for the upcoming 2025 season with spreads for each and every week.
All lines for the 2025 NFL season can be found on the DraftKings Sportsbook
2025 Buffalo Bills Odds
2025 Buffalo Bills Schedule
We’ll update each of these games with odds and lines as they become available on DraftKings Sportsbook.
Week 1: Bills (-1.5) vs. Ravens
Week 2: Bills (-8.5) at Jets
Week 3: Bills (-8.5) vs. Dolphins
Week 4: Bills (-12.5) vs. Saints
Week 5: Bills (-8.5) vs. Patriots
Week 6: Bills (-5.5) at Falcons
Week 7: BYE
Week 8: Bills (-7) at Panthers
Week 9: Bills (-2.5) vs. Chiefs
Week 10: Bills (-5.5) at Dolphins
Week 11: Bills (-5.5) vs. Bucs
Week 12: Bills (-3.5) at Texans
Week 13: Bills (-4.5) at Steelers
Week 14: Bills (-5.5) vs. Bengals
Week 15: Bills (-4.5) at Patriots
Week 16: Bills (-8.5) at Browns
Week 17: Bills (-1.5) vs. Eagles
Week 18: Bills (-9.5) vs. Jets
