The Arizona Cardinals’ 11-6 2021 season feels like it was ages ago. They endured back-to-back 4-13 campaigns, including a head coach turnover. Now things are looking up under the leadership of Jonathan Gannon.
Kyler Murray is healthy after a devastating knee injury. Marvin Harrison Jr. is in the building. Trey McBride is one of the best young tight ends in the league. With an improving defense and a growing cast of studs on offense, perhaps it’s Arizona’s year in the NFC West.
Below, you’ll find Arizona’s full schedule for the upcoming 2025 season, with spreads provided by the DraftKings Sportsbook for each week.
All lines for the 2025 NFL season can be found on DraftKings Sportsbook.
2025 Arizona Cardinals Odds
2025 Arizona Cardinals Schedule
We’ll update each of these games with odds and lines as they become available on DraftKings Sportsbook.
Week 1: Cardinals (-3.5) at Saints
Week 2: Cardinals (-4.5) vs. Panthers
Week 3: Cardinals (+3.5) at 49ers
Week 4: Cardinals (-2.5) vs. Seahawks
Week 5: Cardinals (-5.5) vs. Titans
Week 6: Cardinals (-1.5) at Colts
Week 7: Cardinals (+1.5) vs. Packers
Week 8: BYE
Week 9: Cardinals (+1.5) at Cowboys
Week 10: Cardinals (+1.5) at Seahawks
Week 11: Cardinals (+1.5) vs. 49ers
Week 12: Cardinals (-3) vs. Jaguars
Week 13: Cardinals (+3.5) at Buccaneers
Week 14: Cardinals (+1.5) vs. Rams
Week 15: Cardinals (+2.5) at Texans
Week 16: Cardinals (-3.5) vs. Falcons
Week 17: Cardinals (+3.5) at Bengals
Week 18: Cardinals (+3.5) at Rams
