On Monday morning, it was announced that the 2025 NFL Season Opener will take place on Thursday, September 4, featuring the Dallas Cowboys against the Philadelphia Eagles. This Thursday Night Football matchup will be broadcast on Peacock, starting at 8:20 p.m. ET. Shortly after the announcement, DraftKings Sportsbook released the opening betting lines for the game, providing the first glimpse of odds for a 2025 NFL matchup.
Dallas Cowboys vs. Philadelphia Eagles Opening Lines
The Eagles open as 7-point home favorites, with the game total set at 46.5. Last season, Philadelphia went 14-7 against the spread (ATS), covering by an average of 6.8 points. The Cowboys, meanwhile, finished 7-10 ATS and 4-4 as the road team.
This matchup marks the debut of Dallas’ biggest offseason acquisition, George Pickens. Paired with CeeDee Lamb, Pickens aims to ignite a Cowboys offense that averaged only 20.6 points per game last season. The Eagles’ defense, which led the league by allowing just 18.1 points per game, presents a formidable challenge.
To bet this game, head over to DraftKings Sportsbook to place your first bets of the 2025 NFL Season!
