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MLB DFS Picks: Three must-start fantasy baseball players for Tuesday 5/6/25

MLB DFS Picks: Three must-start fantasy baseball players for Tuesday 5/6/25

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By: Garion Thorne

There’s some notable pitchers taking the mound in tonight’s 12-game MLB featured slate on DraftKings. In fact, with Paul Skenes ($10,000), Zack Wheeler ($9,700) and Chris Sale ($8,800) all taking the mound on Tuesday, this slate includes all three finalists for NL Cy Young in 2024. That’s not too shabby.

Which one should you build your DFS lineups around? Which bats should you pair them with? Let’s break it all down.

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SP Chris Sale, Atlanta Braves vs. Cincinnati Reds, $8,800

Sale didn’t look like himself in his first few outings in 2025, it just took a trip to Coors Field to get him back on track. I know. Don’t overthink it. On April 30, across seven innings of work, Sale allowed just two earned runs and struck out 10, posting a season-high 28.8 FPTS. In all actuality, Sale’s been fine the whole time, he’s simply been a little unlucky. The left-hander’s 3.31 xERA is far more in line with what we’re used to seeing from the veteran and a 29.3% strikeout rate and 14.0% swinging strike rate remain elite. Sale’s just been crushed by a .383 opponent BABIP.

Expect Sale to produce another quality performance on Tuesday in a matchup with the struggling Reds. Cincinnati owns a paltry .128 ISO and 89 wRC+ across the past two weeks and, crucially, this contest isn’t taking place at the always hitter-friendly Great American Ball Park. Sale shouldn’t be priced below $9,000. It’s that simple. Take advantage of this buying window.

OF Byron Buxton, Minnesota Twins vs. Baltimore Orioles, $5,000

Buxton comes into this slate red-hot, slashing .325/.364/.525 over his last 10 games. The Twins haven’t faced many left-handed pitchers in 2025, but when they have, Buxton’s also produced within that split, hitting .364 with a pair of home runs and a triple in only 22 plate appearances. As always, Buxton’s viability is as simple as his health status. The 31-year-old currently looks spry — and he’s on pace to steal a lot of bases — so you might as well get him in some lineups before the inevitable happens.

Cade Povich ($5,000) is a large reason as to why tonight is specifically the night to do that. No Baltimore starter is having a good start to their campaign, but it’s been especially awful for Povich. The southpaw comes into Tuesday in possession of a 5.16 ERA and a 6.08 xERA. He’s also surrendering 2.49 home runs per nine to opposing RHBs. That’s a massive red flag.

OF Tyler Soderstrom, Athletics vs. Seattle Mariners, $4,800

Soderstrom hasn’t hit a home run since April 17, but don’t forget about the Athletics’ slugger. You still want to be investing in Soderstrom as much as you can against right-handed pitching, as the 23-year-old is slashing .284/.368/.549 with a .265 ISO and a 161 wRC+. Soderstrom also still ranks in the 87th percentile or better in barrel rate (15.4%), expected batting average (.300) and expected wOBA (.390). He’s really good.

The RHP in question on Tuesday? Emerson Hancock ($7,000), who sports a 6.62 ERA in the four starts he’s made at the MLB level for Seattle so far in 2025. These aren’t isolated struggles, either. For his career, Hancock owns a 5.08 ERA and a 5.23 FIP across 19 starts. It’s just never worked in the big leagues for the former sixth-overall pick.

Garion is a Toronto-based writer who has been playing fantasy sports since elementary school. With a particular affinity for advanced statistics and sabermetrics, he’s been covering DFS Baseball, Football and Basketball for DraftKings dating back to 2018. Prior to that, Garion’s work could be found at FNTSY, SportsGrid, HoopsHype, The New York Daily News and Sportsnet.ca. Still, he is a Dolphins fan, so his decision-making can be questioned from time-to-time.
Disclaimer

All views expressed are my own. I am an employee of DraftKings and am ineligible to play in public DFS or DKSB contests.