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Kansas City Royals vs. Chicago White Sox prediction, pick for Monday 5/5/25

Kansas City Royals vs. Chicago White Sox prediction, pick for Monday 5/5/25

Published:

By: Dan Johnson

The White Sox are 9-24, staring down a dominant Royals squad that’s 11-5 at home. It’s an uphill battle, especially with the Royals poised to capitalize on a shaky White Sox offense. But, good news—Cole Ragans is back! And Shane Smith might really be something special. Below, I’ve got my preview, prediction, and best bet for this Monday night baseball game between the Royals and the White Sox.

Here’s how I’ll play it. I’ll be pumping out these predictions for individual games all season, with plenty of coverage here on DraftKings Network. Follow my handle @dansby_edits for more betting plays.

Royals vs. White Sox prediction, preview

Shane Smith may have been one of the few bright spots for the White Sox, but tonight’s matchup is tougher than his 2.23 ERA suggests. The Royals, riding high with an 11-5 home record, come in with a pitching staff that’s been stellar at Kauffman Stadium, sporting a 3.00 ERA and a 1.09 WHIP in 16 games. Smith will be challenged by a lineup that’s found a spark, led by Maikel Garcia (.319 AVG) and Vinnie Pasquantino (six HRs, 22 RBIs). Bobby Witt Jr.’s speed and power have further ramped up the Royals’ offense. Kansas City’s timely bursts of power were on full display in their 11-6 win over the Orioles, where they racked up 17 hits. The Royals’ offense may not overwhelm, but it’s finding its rhythm, and their ability to hit with runners on base will likely be the tipping point here.

On the flip side, the White Sox offense continues to struggle, ranking 28th in batting average (.216) and 27th in slugging (.328). With players like Luis Robert (.195 AVG) and Andrew Benintendi (5 HRs), their lineup can’t sustain pressure. Combine that with a bullpen that’s failed to protect leads, and it’s no surprise they’ve struggled on the road with a 3-13 record. Shane Smith may keep them competitive, but a lack of run support and the Royals’ resilience at home will be too much to overcome.

Cole Ragans, though dealing with a recent groin strain, remains crucial. When healthy, he’s been a cleaver, with a 44% strikeout rate facing a lineup the second time through—tops in the league. Ragans’ 3.44 ERA at home this season backs up his ability to silence potent offenses. His K/BB ratio of 3.08 and ability to miss bats (39% strikeout rate against right-handed hitters) gives the Royals confidence. Even a slightly compromised Ragans can keep the White Sox at bay. If Ragans limits base runners early, as he has shown, Kansas City’s defense and bullpen will take care of the rest. His presence, even slightly compromised, puts the Royals in a good position to win.

White Sox vs. Royals pick, best bet

Defensively, the Royals rank among the league’s best with a .989 fielding percentage. Their bullpen, with a 73.3% save rate, locks down close games—something the White Sox are ill-equipped to counter, especially in night games, where they’ve historically underperformed against divisional foes.

The Royals have covered the run line in nine of their last 11. With the White Sox’s inability to generate offense against a pitching staff like Kansas City’s, the run line value is clear. Ragans’ injury concerns are real, but the Royals’ offense and depth outweigh that risk.

This is a bounce-back spot for Ragans. With the Royals’ offense firing on all cylinders, they’re primed for a win.

Best bet: Royals -1.5 (-110) vs. White Sox

Ragans’ Royals roll—tail it with me in the DKN Betting Group here!

Dan Johnson has been an editor, writer, and analyst for DraftKings and DraftKings Network since 2024. He’s previously held editorial posts at The Paris Review, Macmillan Publishers, Bedford/St. Martin’s Press, ASSIGNMENT Magazine, and FantasySixPack. You can find his various editorial work & writing (sports-related and non-) at all of the above.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user (my username is thegreatdansby9) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.