Wednesday is another full day of baseball from coast-to-coast with eight games under the lights split into four in the early wave around 7:00 p.m. ET and four in the later wave around 9:45 p.m. ET. One of the later games from the west coast will take place in San Francisco, where the Giants and Brewers battle by the Bay in the third game of their four-game series. Each team won one of the first two games and will send their Opening Day starting pitcher to the mound. With so many ways to break down the matchup, here are a few of my best bets for Brewers at Giants.
Every game of the season, DraftKings Sportsbook offers multiple ways to get in on the action with player props, moneylines and picks against the spread from each MLB contest. You can also pick series winners, award winners and team futures, as well, so be sure to check out all the options available on the MLB page of DK Sportsbook.
Best Bets for Brewers vs. Giants on DraftKings Sportsbook
Mike Yastrzemski over 1.5 Hits + Runs + RBI (+115)
Yastrzemski went 1-for-2 with two walks on Monday night and got Tuesday off against lefty Jose Quintana. He is hitting .340 this season against righties like opposing starter Freddy Peralta. He has a pair of home runs and a .463 wOBA against righties, as well.
He has also been excellent at home, hitting .368 with two homers and a .543 wOBA. Runs could be hard to come by in this low-scoring game, but if he’s hitting leadoff, he has a good chance to be in the mix of any scoring the Giants are able to do.
With the splits so stacked in his favor, it’s a little surprising to still get Yastrzemski at plus-money to have multiple hits, runs and RBI.
William Contreras over 0.5 RBI (+165)
I’m taking an even longer shot for the second of today’s bets and going with Contreras to pick up an RBI. I played this on Monday night, and he wasn’t able to come through, but he did have chances that he wasn’t able to capitalize on.
On Tuesday night, he had two RBI and has 15 RBI on the season, all of which have come in his last 14 games. He had driven in at least one run in seven of his last eight road games, and 10 of his last 14 overall.
Opposing starter Logan Webb has been excellent this season, but he has given up multiple runs in each of his last two outings and nine runs in 30 innings this season. He hasn’t exactly been unhittable, so the Brewers should be able to scratch together some runs, and Contreras is usually in the heart of all their offensive production.
Giants -1.5 (+164)
The Giants have very attractive +164 odds to win by multiple runs in this matchup of aces, and the betting splits indicate that the sharp money is hammering the Giants against the spread.

The percentage of bets is actually tilted towards the Brewers, but 85% of the handle is on the Giants, indicating the larger bets are stacking up behind Logan Webb and the home team.
The Giants are 15-9 overall and 5-3 at home. Three of their last four wins have come by more than one run, including the first game of this series. They have also won two of Webb’s five starts by multiple runs. Even with Peralta on the other side, getting them at +164 to win by multiple runs is good value.