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MLB DFS Picks: Three must-start fantasy baseball players for Tuesday 4/22/25

MLB DFS Picks: Three must-start fantasy baseball players for Tuesday 4/22/25

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By: Garion Thorne

Tuesday night has a 10-game DraftKings featured slate on the diamond.

Who should you be building your MLB DFS lineups around? I’ve listed my top picks below.

Set your DraftKings fantasy basketball lineups here: NBA $250K Bat Flip [$50K to 1st]


SP Kris Bubic, Kansas City Royals vs. Colorado Rockies, $8,900

You have to be impressed with the way that Bubic has started the season for the Royals. While the 27-year-old probably isn’t quite a good as his 1.88 ERA suggests, a 2.71 FIP is nothing to be ashamed about. Nor is a 26.2% strikeout rate or a 14.5% swinging strike rate — the 10th-highest qualified mark among starting pitchers. Bubic has twice managed to exceed 29.0 DKFP in 2025 and I like his chances of accomplishing that feat a third time on Tuesday. Fortunately for prospective owners, the reasoning has as much to do with matchup as it does Bubic’s recent form.

I probably don’t have to keep reminding people how poorly the Rockies hit away from Coors Field, but I will. As a team, Colorado is slashing .188/.240/.286 within the split with league-worst marks in wOBA (.238) and wRC+ (48). As if that wasn’t enough, the Rockies also sport a 32.5% strikeout rate on the road, which is unsurprisingly the highest rate in MLB. It’s bad times outside of the altitude, guys.


OF Corbin Carroll, Arizona Diamondbacks vs. Tampa Bay Rays, $6,100

While I’d have to imagine that some of the issues that have plagued Zack Littell ($7,000) so far in 2025 have been due to how much he’s pitched in the hitter-friendly confines of George M. Steinbrenner Field, the overall numbers are pretty putrid. Littell comes into tonight’s matchup with the Diamondbacks in possession of a 5.48 ERA and a 5.56 FIP. The right-hander is also allowing an eye-popping 2.35 opponent home runs per nine. The real red flag has been Littell’s complete inability to get out left-handed bats. To wit, lefties are hitting .353 with a .441 wOBA off of the 29-year-old.

Corbin Carroll is left-handed. Corbin Carroll is also in the process of becoming a perennial MVP candidate. In 104 plate appearances this season, Carroll is slashing .323/.394/.645 with seven home runs, 19 RBI and four stolen bases. Carroll is 97th percentile in both expected wOBA (.433) and expected slugging (.652). Simply put, the 24-year-old is a star. He should be in line for a huge performance this evening.


SS Jacob Wilson, Athletics vs. Texas Rangers, $3,300

It remains to be seen if Wilson is a great real-life MLB player, but he’s kind of perfect for DFS. While we all want power and upside in fantasy, Wilson’s ability to put the ball in play is a massive boost to his viability. In 82 plate appearances, Wilson’s produced 79 batted ball events — the sixth-most of any player in the league. That’s what happens when you have a 3.7% strikeout rate and haven’t drawn a single walk all season. It also helps that the free-swinging Wilson is batting .354 with a 152 wRC+.

Tonight, Wilson and the Athletics will face-off with Patrick Corbin ($6,000). The last time the A’s saw a left-handed starter back on April 12, it was Wilson who hit in the team’s leadoff spot. I expect he’ll do that again this evening. Wilson doesn’t have a huge sample at the MLB level against LHPs, yet in 32 plate appearances, the rookie is hitting .300 with a .233 ISO and a 150 wRC+. At this price, in a matchup with a washed-up Corbin, Wilson could be one of the best values on the whole slate.

Garion is a Toronto-based writer who has been playing fantasy sports since elementary school. With a particular affinity for advanced statistics and sabermetrics, he’s been covering DFS Baseball, Football and Basketball for DraftKings dating back to 2018. Prior to that, Garion’s work could be found at FNTSY, SportsGrid, HoopsHype, The New York Daily News and Sportsnet.ca. Still, he is a Dolphins fan, so his decision-making can be questioned from time-to-time.
Disclaimer

All views expressed are my own. I am an employee of DraftKings and am ineligible to play in public DFS or DKSB contests.