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DraftKings MLB Pick6 Fantasy Baseball Picks Today: Top Picks for Tuesday 4/22/25

DraftKings MLB Pick6 Fantasy Baseball Picks Today: Top Picks for Tuesday 4/22/25

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By: Bryan Armetta

A loaded 30-game, 15-team slate is on tap for Tuesday across Major League Baseball. Among the matchups to watch, the rival Yankees and Guardians meet once again in Cleveland. Elsewhere, the Phillies and Mets will take the field following Monday’s dramatic 5-4 New York win. Later, the Dodgers and Cubs face off at Wrigley Field in a battle of playoff contenders.

There’s plenty of ways to get in on the action with DraftKings MLB Pick6 fantasy baseball selections before tonight’s contests!


Jack Flaherty less than 5.5 strikeouts

Detroit, with a record of 14-9, has built its AL Central lead thanks to pitching. Even without Cy Young winner Tarik Skubal, the Tigers have built a lethal rotation of veterans and promising arms. That includes Jack Flaherty, who signed on for his second career stint with the team this offseason. Through four starts, the 29-year-old has recorded a 2.53 ERA to go with 25 strikeouts and a 1.08 WHIP.

As good as those numbers are, last week’s appearance vs. Milwaukee (4.2 IP, 3 ER) wasn’t ideal. Flaherty will have a much tougher task tonight against a Padres team that knows how to take pitches. This season, San Diego has struck out 6.43 times per game, the lowest mark in baseball. The right-hander might find success on Tuesday, but it likely won’t come via punch outs.

Bryce Miller more than 5.5 strikeouts

Much like Detroit, the Mariners have assembled one of the sport’s best pitching staffs. It’s been a mixed bag for Bryce Miller; in spite of a solid ERA (3.43), he’s put plenty of runners on base (1.33 WHIP). However, the starter has seen his K/9 ratio rise to a career-best 9.0. Going forward, it’s fair to expect even better numbers from the 26-year-old.

That should be the case on Tuesday against a free-swinging Red Sox team. Through 24 contests, Boston ranks third in the league in strikeouts per game (9.38). Last spring, Miller notched six strikeouts over five innings vs. the BoSox. Following an eight-K performance last Wednesday, Seattle’s young arm is poised for success tonight.

Francisco Lindor more than 1.5 hits + runs + RBIs

It took some time, but Francisco Lindor is finally back on track. Following a rough first few weeks, the All-Star has hit .429 with four home runs and seven RBIs during his previous ten games. That includes Monday’s two-homer performance against elite Phillies pitching.

The Mets will hope for an encore tonight against Philadelphia when Christoper Sanchez takes the mound. Lindor has gone 3-for-9 in his career against the starter. However, as a switch-hitter, there’s a good chance he can get something going on Tuesday. For his career, Sanchez has allowed a .260 batting average to right-handed hitters. In the midst of a hot streak, it’s impossible to fade New York’s face of the franchise right now.

Davis Martin more than 2.5 earned runs allowed

Once again, the White Sox and their 5-17 record are a national embarrassment. The rebuilding South Siders don’t have much talent at the major league level, including their rotation. One of the staff ‘aces’ is Davis Martin (4.84 ERA, 1.48 WHIP). Following a decent 2024 campaign, the 28-year-old has gotten off to a rough start. In his most recent start, vs. the Athletics, he was tagged for four runs over 5.1 innings.

Tonight, Chicago will go on the road for an AL Central showdown against the Twins. In his career, Minnesota has tagged Martin for 13 earned runs over 10.1 innings (11.32 ERA). In addition, the White Sox have let the right-hander go at least five innings in all three of his starts this year. This is the perfect combination of bad matchup and enough innings to go over this total.

Byron Buxton more than 0.5 RBIs

Let’s stay in Minneapolis, where the Twins will hope to hammer the White Sox. Byron Buxton is key to Minnesota’s success, regardless of the opponent. The perpetually injured outfielder has gotten off to a decent start in 2024. Through 20 games, he’s recorded a .244 batting average, four home runs and ten RBIs.

As previously mentioned, Chicago starter Davis Martin has pitched to an 11.32 ERA over three starts vs. Minnesota. If another poor outing occurs tonight, the Twins should have plenty of traffic on the base paths. Buxton has tallied an RBI and at least two hits in three of his last four appearances this season. It’s fair to expect another productive evening from the former All-Star on Tuesday.

Jose Quintana less than 2.5 earned runs allowed

Despite missing several starters, the Brewers have managed to stay above .500 through the first month of the season. Much of the credit goes to a pitching staff filled with savvy, under-the-radar signings. That includes Jose Quintana; over 12.2 innings pitched, he’s surrendered one earned run (0.71 ERA). Despite a lack of strikeouts (six), the veteran has a knack for inducing weak contact.

Quintana doesn’t induce many whiffs, but that also allows him to pitch deeper into games. Over eight career starts at Oracle Park, opponents have hit just .212 against the 36-year-old. The Giants have also hit .212 this season when facing left-handed pitchers. A pro’s pro such as Quintana is a solid pick to log five efficient innings during tonight’s West Coast matchup.

What is DraftKings Pick6?

Pick6 is a peer-to-peer fantasy variant where you build a lineup (your “Pick Set”) of 2+ players and select whether or not you believe each will outperform their listed stat projection. Enter your Pick Set in Pick6 contests to compete against other users. Get enough picks correct and win a share of cash prizes.


How to Play DraftKings Pick6

Create a Pick Set

Create a Pick Set by choosing 2+ players from the same sport and Pick Group (a set of picks available from a group of set competitions). For each player, simply select if you think they’ll have more or less than their listed stat projection. In each Pick Set, you can not pick the same player twice and you must pick players from at least two different teams.

Enter an Amount

Once you finalize your Pick Set, choose your entry fee amount. Your entries will be automatically distributed into available contests, subject to your confirmation.

Sweat Your Picks

When the games go live, use the My Picks tab to follow your picks in real time to track how your players are performing against their projections and how they stack up against other users.

Compete for Prizes

Make enough correct picks and win a share of the contests’ guaranteed prizes. Any prizes won will be credited to your DraftKings account after contests are finalized.

Play at DraftKings Pick6 or by downloading the DraftKings Pick6 app on Apple or Google!


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Google DraftKings Pick6 App


Gambling Problem? Call 1-800-GAMBLER. Must be at least 18 years or older. Higher age limits may apply in some states. Eligibility restrictions apply. Valid only in states where DraftKings Pick6 operates. Void where prohibited. For entertainment purposes only. Winning a contest on DraftKings depends on knowledge and exercise of skill. See terms at pick6.draftkings.com.

Bryan Armetta is a New York-based writer that has spent over eight years in sports media. Working for DraftKings since 2024, he currently serves as a writer, editor and analyst for all things sports and pop culture. Bryan specializes in MLB, NBA, NFL, college sports and entertainment content. Prior to his time at DKN, he worked for MLB Network, NHL Network and SiriusXM Sports.
Disclaimer

I am a promoter at DraftKings and am also an avid fan and user and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.