Today’s MLB Starting Pitcher list is here for your viewing pleasure. Here, you’ll see the matchups, opening lines, and times the games are scheduled to begin. All odds and lines are provided by DraftKings Sportsbook.
For daily fantasy and betting information on this slate, visit DraftKings Network for daily MLB content and news.
MLB Starting Pitchers for April 21st, 2025
Chicago White Sox: Jonathan Cannon +245
Boston Red Sox: Walker Buehler -305
11:10 p.m. ET
New York Yankees: Clarke Schmidt -120
Cleveland Guardians: Gavin Williams +100
6:10 p.m. ET
Cincinnati Reds: Nick Lodolo -125
Miami Marlins: Max Meyer +105
6:40 p.m. ET
San Diego Padres: Randy Vasquez +110
Detroit Tigers: Keider Montero -130
6:40 p.m. ET
Philadelphia Phillies: Aaron Nola +105
New York Mets: Tylor Megill -125
7:10 p.m. ET
St. Louis Cardinals: Erick Fedde +160
Atlanta Braves: Spencer Schwellenbach -192
7:05 p.m. ET
Toronto Blue Jays: Kevin Gausman +120
Houston Astros: Hunter Brown -142
8:10 p.m. ET
Milwaukee Brewers: Quinn Priester +120
San Francisco Giants: Robbie Ray -142
9:45 p.m. ET
For daily fantasy and betting information on this slate, visit DraftKings Network for daily MLB content and news.
Follow me @SBuchanan24 on Twitter for daily MLB info and bets, including daily betting information about the most bet props, games and teams.
