After a busy afternoon of baseball, DraftKings closes out a great sports Saturday with a four-game MLB DFS slate that includes eight teams in action at 7:10 p.m. ET or later. The Saturday night slate includes the team with the best record in the MLB, along with some teams trying to find their footing. The last matchup of the night is also an intriguing one between a pair of California teams trying to prove their strong bounce-back starts to the season are legitimate. It’s a limited slate, but the eight teams offer some good MLB DFS picks to consider for your lineup.
Let’s dive into the player pool and take a look at my top MLB DFS picks for Saturday night’s contest.
Set your DraftKings fantasy baseball lineups here: MLB $80K Relay Throw [$20K to 1st] (Night)
PITCHER
Stud
Chris Sale, Atlanta Braves vs. Minnesota Twins $9,500: Along with the Braves as a whole, Sale has stumbled at the start of the season, going 0-2 with a 6.63 ERA. However, his FIP is still decent at 3.66, and his 4.30 xERA shows he has also been a little unlucky. His strikeout rate has also been consistent at 11.4 K/9 this season, with 24 strikeouts in 19 innings. Those strikeouts have helped him produce at least 11 DraftKings fantasy points in three of his four outings.
If there’s a get-right spot for Sale, though, this home matchup against the Twins should be it. Minnesota has the lowest implied run total on Saturday night’s slate and the lowest team wOBA of the eight teams in action. In their 20 games, the Twins have scored just 3.5 runs per game with a .214 team batting average.
Against lefties, the Twins’ numbers are even worse. In the split, they are hitting just .118 as a team with an MLB-high 33.1% K% against southpaws. They have a paltry .176 team wOBA against lefties and only a 13 wRC+. The way wRC+ is figured out, 100 is the league average by definition, and the Twins as a team are 87% below league average against lefties like Sale. Yikes!
The Braves rallied to a win in the series opener on Friday, and they’ll look for Sale to right the ship and navigate them to another victory on Saturday.
Value
Landen Roupp, San Francisco Giants at Los Angeles Angels, $7,500: Roupp is a solid option with good upside from just below halfway in the starting pitcher salary spectrum. The 26-year-old righty earned a spot in the rotation this spring training after working out of the bullpen last year. He had a lights-out spring training, tossing 8 1/3 scoreless frames with just two hits allowed and 11 strikeouts before getting knocked around by the Cubs in his final Cactus League appearance.
He started the season strong with eight strikeouts in four innings for 14.2 fantasy points against the Astros. He went six one-run innings in his next start against the Reds, and then posted a season-high 17.9 fantasy points against the Phillies. He gave up three runs in the first inning of that outing in Philly, but settled down and finished with eight strikeouts and 101 pitches in five innings to earn his first win of the season.
With 20 strikeouts in 15 innings, he has a very high ceiling in this matchup against the Angels, who have scored three runs or fewer in five straight games. Over the last week, the Angels lead the MLB with a 34.2% K% while hitting only .196. Roupp will look to continue their struggles and be an excellent value arm Saturday night.
INFIELD
Stud
Tyler Soderstrom, Athletics at Milwaukee Brewers, $5,300: Soderstrom has led a much-improved Athletics offense this season and leads the major leagues with nine home runs on the season. In his 20 games, he is hitting .325 with a .458 wOBA, 19 RBI and an average of 11.5 fantasy points per game. While I had Soderstrom as one of my top breakout 1B of the season, I didn’t see him being this good right out of the gate.
Soderstrom picked up two more hits in Friday night’s loss to the Brewers and has at least eight fantasy points in three of his last four games. He has an extremely high ceiling and has been consistent enough to be a great option to build around this Saturday night.
Stud
Zach Neto, Los Angeles Angels vs. San Francisco Giants $3,900: While he’s somewhere in the midrange between a stud and a value in today’s MLB DFS picks, Neto makes sense as a play this Saturday night, however you want to classify him. He brings stud upside but is a good value since he just came off IL. In his first game of the season, he went one-for-three with a double, an RBI, a run scored and nine fantasy points. In a 2-0 win over the Giants, he literally was the Angels offense.
Neto was another player I liked to have a breakout season, but his season is just starting since he needed extra time to recover from offseason shoulder surgery. In Triple-A, Neto hit .286 with four homers and a .430 wOBA in 13 games and also stole a base. Last season, he had 30 stolen bases to go with 23 homers and a .330 wOBA. Even if he isn’t ready to run quite as much yet, he brings plenty of power and dual-threat upside from this salary just under $4,000.
Value
Jose Iglesias, San Diego Padres at Houston Astros, $2,800: After becoming a little bit of a cult hero in New York for the Mets last season, Iglesias has taken his show to San Diego and been a great fill-in at 2B for Jake Cronenworth (ribs). He has hit safely in five straight contests, going seven-for-18 (.389) with three doubles, a stolen base, and an average of 9.2 DraftKings points per game.
For the season, he’s hitting exactly .300 with a .324 wOBA and one stolen base. While he doesn’t typically hit for a ton of power, his consistent contact and excellent defense is enough to keep him in San Diego’s lineup and make him a decent contributor as a cheap fantasy play as well.
OUTFIELD
Stud
Fernando Tatis Jr., San Diego Padres at Houston Astros, $6,000: Tatis has started the season hitting a red-hot .342 with six home runs, six stolen bases, 17 runs scored, 14 RBI and a .438 wOBA. he has produced 12.3 fantasy points per game so far this year, and the scary thing is that his metrics indicate he could be even better than those numbers indicate. He has a 50.8% hard-hit rate and 18.5% barrel rate that gives him an even higher .481 xwOBA.
He and the Padres face Hayden Wesneski ($8,200), who has been solid but not unhittable for the Astros this season. Tatis has hit safely in seven straight, with four games of at least nine fantasy points during that stretch.
Stud
Michael Harris II, Atlanta Braves vs. Minnesota Twins, $4,400: With Alex Verdugo ($3,000) in the leadoff spot, Harris dropped back to seventh in the order on Friday night and responded with two hits, a stolen base and 17 fantasy points. He struggled while filling in for Ronald Acuna Jr. (knee) at the top of the order but looked much more comfortable on Friday. Simeon Woods Richardson ($6,500) has been hammered by lefties this season. In his first three starts, lefties are hitting .423 with a .475 wOBA, making the Braves’ left-handed hitters strong MLB DFS picks.
Value
Cam Smith, Houston Astros vs. San Diego Padres, $2,600: Since he played only 32 minor-league games in his career, it isn’t surprising that Smith needed some time to adjust to the MLB level. He started the year two-for-18 with just two singles, but he has caught fire since then, going nine-for-31 (.290) since then with a triple, three home runs, and a 40% hard-hit rate. He went two-for-four with two home runs for 32 fantasy points on Friday night
First career multi-homer game for Cam Smith! pic.twitter.com/Qv3Lilxhf1
— MLB (@MLB) April 19, 2025
Now that he’s settled, he will look to overcome that slow start and definitely brings a high ceiling for an outfield option under $3,000. He’s a great value option in my MLB DFS picks for Saturday night and leaves lots of salary available for other pay-up plays.
