At Lucas Oil Stadium on Sunday, Nov. 10, the Buffalo Bills meet the Indianapolis Colts, starting at 1 p.m. ET. The Bills should win, according to our computer model — continue scrolling to find more tips about the point spread, over/under and even the final score.
Sign up for DraftKings Sportsbook and place your bets today!
Bills vs. Colts Predictions
- Our prediction to win on the Moneyline in this contest is the Bills, by a final score of Bills 26, Colts 20.
- Against the spread, we project that the Bills will cover. The spread is currently Bills -3.5.
- As for the total, we see this one going under the posted over/under of 46.5 points. Our projected total for the match is 45.2 points.
Bills vs. Colts Odds
- Spread favorite: Bills (-3.5)
- Moneyline: Bills (-205), Colts (+170)
- Total: 46.5 points
Bills Betting Trends
- The Bills’ ATS record is 5-4-0 this season.
- In games it has played as at least 3.5-point favorites this season, Buffalo is 2-2 against the spread.
- Bills games with a set total have hit the over five times this season (55.6%).
- The Bills have been the moneyline favorite a total of six times this season, and they’ve won each of those games.
- Buffalo has played in four games as a moneyline favorite with odds of -205 or shorter and won every time.
Colts Betting Trends
- So far this year, the Colts have put together a 7-2-0 record against the spread.
- When it has played as at least 3.5-point underdogs this year, Indianapolis is 2-1 against the spread.
- Colts games have hit the over in three out of nine opportunities (33.3%).
- The Colts have entered the game as underdogs six times this season and won twice.
- This season, Indianapolis has been at least a +170 underdog on the moneyline two times, losing each of those contests.
Place your NFL bets online at DraftKings Sportsbook today!
Bills Key Stats
- Total offense: 335.2 yards per game, 16th in NFL
- Passing offense: 216.1 yards per game, 16th in NFL
- Rushing offense: 119.1 yards per game, 17th in NFL
- Total defense: 333.3 yards per game, 17th in NFL
- Passing defense: 209.9 yards per game, 16th in NFL
- Rushing defense: 123.4 yards per game, 15th in NFL
Colts Key Stats
- Total offense: 315.0 yards per game, 22nd in NFL
- Passing offense: 193.7 yards per game, 22nd in NFL
- Rushing offense: 121.3 yards per game, 16th in NFL
- Total defense: 383.6 yards per game, 29th in NFL
- Passing defense: 233.8 yards per game, 26th in NFL
- Rushing defense: 149.8 yards per game, 31st in NFL
Download DraftKings and experience the ultimate host for games and betting experiences!
This article contains AI-generated editorial insights provided by Data Skrive.
The Crown Is Yours: Sign up for DraftKings and experience the ultimate host for games and betting experiences!
All odds provided by DraftKings Sportsbook and all odds subject to change.