Week 6 in the NFL should be a fantastic week of football. For the second straight week, there are 14 matchups as part of the week with an early Sunday game from London along with the three primetime matchups on Thursday, Sunday, and Monday night. There are 10 games scheduled for Sunday afternoon with six in the early wave and four starting after 4:00 p.m. ET. All across the schedule, there are great matchups with exciting storylines.
The Chiefs, Rams, Dolphins, and Vikings are on a bye this week while the Lions, Chargers, Eagles, and Titans are returning from their bye in Week 5.
Each week, I’ll post the relevant info for the biggest matchups from DraftKings Sportsbook to help you find the stats and trends that matter. You can use these numbers to fill out your Week 5 betting card with single bets or combine them into an awesome parlay. Just a quick reminder before we begin: “SU” means “Straight Up,” while “ATS” stands for “Against the Spread.” Spreads used in records are taken from DraftKings Sportsbook at the kickoff of each game.
Make sure to check out our betting splits table as well, where you can see where the public is leaning in each matchup.
Make sure to check throughout the DK Network for more insight on NFL betting picks, NFL DFS contests, and more specific insights on player props, matchups, and strategies throughout the upcoming season.
Below are the betting trends for the top five matchups of Week 6:
All odds are provided by DraftKings Sportsbook and all odds are subject to change.
San Francisco 49ers at Seattle Seahawks
Relevant Records
Betting Trends
This NFC West battle kicks off Week 6 from Seattle. The Seahawks have a one-game lead in the division over the 49ers and the Cardinals after their 3-2 SU/1-3-1 ATS start to the season. The 49ers have survived without Christian McCaffrey (calf) but are 2-3 SU/ATS. Both teams are coming off SU/ATS home losses as the favorites last week.
The 49ers are 12-5 ATS in their last 17 divisional games but only 2-7 ATS in their last nine overall. They are 0-2 SU in their two games as road favorites this year, but they have gone 5-1 SU/4-1 ATS in their last five head-to-head matchups with the Seahawks.
Seattle has also struggled ATS lately going 1-5-1 in its last seven games overall. However, the Seahawks are 10-3 SU in their last 13 home games against the 49ers and 12-4 ATS in their last 16 home games in this divisional matchup. The Seahawks are 3-11 SU in their last 14 as underdogs in general but are 5-2 in their last seven as home underdogs.
The under is 7-2 in Seattle’s last nine games as home underdogs, but the over is 4-1 in its last five games and 6-2 in its last eight home games. The over is also 5-2 in the 49ers’ last seven games and 8-2 in their last 10 divisional contests.
Jacksonville Jaguars vs. Chicago Bears
Relevant Records
Betting Trends
The Jags roll into London after their first SU win of the season and the Bears are also riding high after trouncing the Panthers last week. The Bears are 3-2 SU/4-1 ATS in their first year with Caleb Williams at QB and will officially be the home team for this matchup, which will be played at Tottenham Hotspur Stadium in north London at 9:30 a.m. ET.
The Jaguars are 1-5 SU in their last five games, 0-6 SU in their last six road games, and 0-7 SU in their last seven games vs. the NFC North. They are also just 3-8 ATS in their last 11 games and 2-5 ATS in their last seven games against the Bears.
The Bears are 8-3-1 ATS in their last 12 games dating back to last year and have scored first in eight of their last 10 contests. They have also covered the first-half spread in 13 of their last 20 games. Part of their recent success has been their strong defense since they have held opponents to 21 points or less in 11 straight games.
The under has been a strong recent trend for both teams. It is 10-5 in the Bears’ last 15 games and 6-3 in the Jaguars’ last nine games.
Washington Commanders vs. Baltimore Ravens
Relevant Records
Betting Trends
This will be an awesome matchup highlighting two of the most dynamic QBs in the game as Lamar Jackson’s Ravens host Jayden Daniels’ Commanders. Last week, the Ravens rallied to beat the Bengals and improve to 3-2 SU/2-3 ATS on the season while the Commanders won convincingly at home vs. the Browns to improve to 4-1 SU/ATS. Both teams begin the week at the top of their divisions.
The Commanders are 7-2-1 ATS in their last 10 games vs. the AFC North and have hit the 1H Game Total Over in 12 of their last 20 games. While they are only 5-10 SU in their last 15 games in October, they have gone 6-2 SU in their last eight games played in Week 6.
On the other side, the Ravens are 14-5 SU in their last 19 games and 13-6 SU in their last 19 games at home. They are also an impressive 10-0 SU in their last 10 games vs. the NFC.
The over is a strong trend for both teams, going a combined 8-2 in their 10 games so far this season. While the under is 5-2 in the last seven head-to-head meetings between these teams, the over is 6-1 in Washington’s last seven road games, 5-2 in its last seven games vs. the AFC, and 5-2 in the Ravens’ last seven vs. the NFC East.
Cincinnati Bengals vs. New York Giants
Relevant Records
Betting Trends
The Bengals lost in overtime to the Ravens last week after seemingly having the game in hand. Meanwhile, the Giants went on the road and got a big win over the Seahawks. They’ll be the underdog for the sixth straight time in this game, despite their 2-3 SU/3-2 ATS record this season compared to the 1-4 SU/2-3 ATS record of the Bengals.
The Bengals are 6-3 ATS in their last nine meetings with the Giants but only 2-5 SU in their last seven head-to-head meetings. They are also 0-5 SU in their last five games vs. the NFC East but 10-1 SU in their last 11 vs. the NFC in general. Cincinnati has been especially good on the road lately, going 18-6 ATS in their last 24 Sunday road games.
The Giants are 8-2-1 ATS in their last 11 games vs. the AFC and 9-3 ATS in their last 12 as the underdog. They are also 9-3 ATS in their last 12 overall and 5-1 ATS in their last six home games.
The under is 5-1 in the Giants’ last six home games, 10-1 in their last 11 vs. the AFC, and 4-1 in the last five games in this series. However, the over is 5-1 in the Bengals’ last six games.
Buffalo Bills vs. New York Jets
Relevant Records
Betting Trends
The Jets surprised the football world by firing coach Robert Saleh earlier this week, and they’ll hope that jump-starts their season which began 2-3 SU/2-3 ATS after losing last week in London to the Vikings. The Bills are 3-2 SU/2-3 ATS after dropping two straight to the Ravens and Texans after their 3-0 start to the year. The Bills start the week a game ahead of the Jets and Dolphins for the lead in the AFC East.
Buffalo is 10-2 SU in its last 12 divisional games and 8-1 SU in its last nine games as the favorite. The Bills are also 9-3 SU in their last 12 games overall and 6-2 SU in their last eight games vs. the Jets. The only downward trend for the Bills is that they are 0-5 ATS in their last five games played in October.
The Jets will hope for the famous “new coach bounce” after going 5-10 SU/4-11 ATS in their last 15 games under Saleh. They are also only 2-5 ATS in their last seven home games, 5-15 SU in their last 20 divisional games, and 2-8 ATS in their last 10 games as the underdog.
The under is 11-1 in the Jets’ last 12 divisional games and 15-4 in the Bills’ last 19 road games. The under is also 4-2 in the Jets’ last six games overall and 4-1 in the last five games in this series.
All odds provided by DraftKings Sportsbook and all odds subject to change.
The Crown Is Yours: Sign up for DraftKings and experience the ultimate host for games and betting experiences!
I am a promoter at DraftKings and am also an avid fan and user (my username is z.thompson) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skill and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.
