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2022 NFL Week 10 Best Bets

Pat Mayo gives his best bets on DraftKings Sportsbook for Week 10 of the NFL season.

Pat Mayo, Rob Pizzola and Cam Stewart give their 2022 NFL Week 10 best bets on DraftKings Sportsbook with their Gold, Silver and Bronze Selections of the Week.

Week 10 Rankings, Injury List, DraftKings Notes


Week 10 RankingsGame Picks/Previews | Rankings | RB | WR | TE | QB | DST

Week 10Spread Picks | Best Bets | RB Snaps | W10 Game Lines | Projections

GET LINK TO PME DRAFTKINGS RAKE FREE CONTEST

How to Use DK Tools — Optimizer | Game Sims | Player vs Player Compare

Podcasts — YouTube | Apple | Spotify | Insta | Google | Twitter | E-Mail

Week 10 Spread Picks for Every Game


2022 NFL Week 10 Best Bets: Gold Picks

Mayo: CLE +4
Pizzola: DET +3
Cam: DEN +2

2022 NFL Week 10 Best Bets: Silver Picks

Mayo: DAL -4.5
Pizzola: PIT +1.5
Cam: CLE +4

2022 NFL Week 10 Best Bets: Bronze Picks

Mayo: SEA +2.5
Pizzola: JAX +9.5
Cam: DET +3

2022 NFL Week 10 Best Bets: Last Week

Gold: 1-1-1 (15-10-2)
Silver: 2-0-1 (13-13-1)
Bronze: 2-0-1 (13-12-2)

2022 NFL Week 10 Best Bets: Season Record

Mayo: Gold 5-3-1; Silver 4-5; Bronze 4-4-1
Pizzola: Gold 6-3; Silver 4-4-1; Bronze 4-5
Cam: Gold 4-4-1; Silver 5-4; Bronze 5-3-1

*All lines from DraftKings Sportsbook

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All odds provided by DraftKings Sportsbook and all odds subject to change.


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Pat Mayo is an award-winning video host and producer of long and short-form content, and the host of The Pat Mayo Experience daily talk show. (Subscribe for video or audio). Mayo (@ThePME) won the 2022 Fantasy Sports Writing Association Daily Fantasy Writer of the Year and was a finalist for three FSWA Awards (Best Podcast, Daily Fantasy Writer of the Year, Golf Writer of the Year). His 24 FSWA nominations lead all writers this decade and are second-most all-time.

Mayo has been recognized across multiple sports (Football, Baseball & Golf), mediums (Video, Writing & Podcasting), genre (Humor), and game formats (Sports Betting, Daily Fantasy, and Traditional Season Long Fantasy).


I am a promoter at DraftKings and am also an avid fan and user (my username is ThePME) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skill and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.