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NFL 2021 Week 1 DraftKings Picks: Fantasy Football Start, Sit, Sleepers

Pat Mayo goes position-by-position breaking down the Sunday NFL slate, giving his Week 1 DraftKings picks for GPPs.

Pat Mayo and Adam Levitan go position-by-position, providing their Week 1 DraftKings Picks for the NFL Sunday Main Slate.

Week 1 Ranks, Injuries, Plays/Fades, Player Notes

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Week 1 — Rankings | Injuries | RB | WR | QB | TE | DST | Projections

Week 1 — Best Bets | Spread Picks | TNF DK Showdown | Start/Sit | Props

Week 1 DraftKings — DK Picks | Stacks | Optimizer | Obvious Picks

Play in RAKE FREE Week 1 PME DraftKings League

How to Use DK Tools — Optimizer | Game Sims | Player vs Player Compare

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2021 NFL Week 1 DraftKings Picks: Show Index

00:00 Intro
1:47 Strategy + Tools
5:41 Week 1 Overview
8:06 RB
23:31 WR
46:19 TE
57:57 DST
1:00:57 Play The Best Plays
1:07:06 Optimizer Lineup

2021 NFL Week 1 DraftKings Picks: Tournament Plays (GPPs)

Player Projections | Advanced Stats | How to Use DraftKings Tools

Tournament plays are more volatile players (boom or bust) who can help differentiate your lineup in giant GPPs. Mixing a few of these names, along with the safer cash-game options, is a great way to construct a GPP roster.


Jalen Hurts $6,400
Trevor Lawrence $6,200
Sam Darnold $5,000

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Alvin Kamara $8,600
James Robinson $6,400
Najee Harris $6,300
Mike Davis $5,400

How To Bet on NFL — Guide + Strategy | Podcast | For Beginners | Gambling Myths


Calvin Ridley $7,900
Robby Anderson $5,700
Corey Davis $4,900
Marvin Jones $3,600
Marquez Callaway $3,400

How to Use DK Tools — Optimizer | Game Sims | Player vs Player Compare


Travis Kelce $8,300
Kyle Pitts $4,400
Tyler Kroft $2,500


Broncos $3,300
Bills $2,500
Falcons $2,000

NOTE: Picks for Sunday’s main slate only

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Pat Mayo is an award-winning video host and producer of long and short-form content, and the host of The Pat Mayo Experience daily talk show. (Subscribe for video or audio). Mayo (@ThePME) won the 2020 Fantasy Sports Writing Association Daily Fantasy Writer of the Year and Golf Writer of the Year awards, along with the Fantasy Sports Trade Association Best Sports Betting Analyst award, and was a finalist for four FSWA Awards in 2020 (Best Podcast, Best Video, Daily Fantasy Writer of the Year, Golf Writer of the Year). His 21 FSWA nominations lead all writers this decade and are third-most all-time. Mayo has been recognized across multiple sports (Football, Baseball & Golf), mediums (Video, Writing & Podcasting), genre (Humor), and game formats (Daily Fantasy and Traditions Season Long). Beyond sports, Mayo covers everything from entertainment to pop culture to politics. If you have a fantasy question, general inquiry or snarky comment, ship it to Mayo at and the best will be addressed on the show.

I am a promoter at DraftKings and am also an avid fan and user (my username is ThePME) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.

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