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2021 Week 16 NFL Spread Picks, Predictions, Game Previews, Survivor Picks

Pat Mayo, Geoff Fienberg and Tim Anderson go game-by-game and make their 2021 NFL Week 16 picks against the spread.

Pat Mayo, Geoff Fienberg and Tim Anderson go game-by-game and make their 2021 NFL Week 16 Picks against the spread while providing their Week 16 NFL game previews.

Week 16 Weekend Injury


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Game-by-Game Picks

Week 16 — Best Bets | Game Picks | Injury Report | DK Picks

Week 16 — Rankings | RB | WR | TE | QB | DST | Projections

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WEEK 16 NFL SPREAD PICKS: CHEATSHEET

Note: The Coin is literally a flipped coin

MAYO: SF -3.5, CLE +7.5, ARZ -1.5, PHI -10, MIN +3, BUF +2.5, CAR +10.5, JAX +2.5, ATL -5.5, HOU +9, CIN -2.5, CHI +7, LV -1.5, KC -9.5, DAL -10.5, NO -3

GEOFF: SF -3.5, CLE +7.5, ARZ -1.5, PHI -10, MIN +3, BUF +2.5, CAR +10.5, JAX +2.5, ATL -5.5, LAC -9, BAL +2.5, CHI +7, DEN +1.5, KC -9.5, DAL -10.5, NO -3

CUST: TEN +3.5, GB -7.5, IND +1.5, PHI -10, MIN +3, NE -2.5, CAR +10.5, NYJ -2.5, DET +5.5, LAC -9, BAL +2.5, SEA -7, DEN +1.5, PIT +9.5, WAS +10.5, MIA +3

THE COIN: TEN +3.5, GB -7.5, ARZ -1.5, PHI -10, MIN +3, BUF +2.5, TB -10.5, NYJ -2.5, DET +5.5, HOU +9, CIN -2.5, CHI +7, LV -1.5, PIT +9.5, DAL -10.5, MIA +3

2021 Last Week Record (Season Record)

MAYO: 12–4 (118-106)

GEOFF: 6-10 (118-106)

CUST: 9-7 (111-113)

COIN: 12-4 (111-113)

SUPERLOCK (RECORD)

MAYO: SF -3.5 (12-3)

GEOFF: KC -9.5 (9-6)

CUST: GB -7.5 (7-8)

SURVIVOR (USED)

MAYO: OUT!!!!! (LAR/CLE/DEN/BUF/TB/KC/ARZ/CIN)

GEOFF: OUT!!!!! (LAR/CLE/DEN/BUF/NE/IND/ARZ/LAC)

CUST: OUT!!!!! (LAR/CLE/DEN/TEN)

CUST “FREE MONEY” PICKS

6-POINT TEASER: GB -1.5/IND -7.5/DET +11.5/BAL +8.5/KC -3.5/MIA +9

Cust’s 2021 Record 5-13
Cust’s Lifetime Record: 14-97

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Pat Mayo is an award-winning video host and producer of long and short-form content, and the host of The Pat Mayo Experience daily talk show. (Subscribe for video or audio). Mayo (@ThePME) won the 2020 Fantasy Sports Writing Association Daily Fantasy Writer of the Year and Golf Writer of the Year awards, along with the Fantasy Sports Trade Association Best Sports Betting Analyst award, and was a finalist for four FSWA Awards in 2020 (Best Podcast, Best Video, Daily Fantasy Writer of the Year, Golf Writer of the Year). His 21 FSWA nominations lead all writers this decade and are third-most all-time. Mayo has been recognized across multiple sports (Football, Baseball & Golf), mediums (Video, Writing & Podcasting), genre (Humor), and game formats (Daily Fantasy and Traditions Season Long). Beyond sports, Mayo covers everything from entertainment to pop culture to politics. If you have a fantasy question, general inquiry or snarky comment, ship it to Mayo at ThePatMayoExperience@gmail.com and the best will be addressed on the show.


I am a promoter at DraftKings and am also an avid fan and user (my username is ThePME) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skill and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.


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