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The NFL announced the complete 2022 schedule on Thursday, and the Arizona Cardinals are officially set to kick off their 2022 season against the Kansas City Chiefs at 4:25 p.m. ET on CBS. Their first divisional game will be in Week 3 against the Los Angeles Rams at home.
The Cardinals went 11-6 in 2021 and finished second in the AFC West. They made the playoffs but lost to the Los Angeles Rams in the Wild Card round. They signed running back James Conner to a 3-year, $21 million deal and TE Zach Ertz to a 3-year, $31.65 million contract as their most significant moves in free agency.
Arizona drafted a tight end with its first NFL draft pick in the second round. They drafted two defensive ends to try and make up for the loss of Chandler Jones. The Cardinals traded for wide receiver Marquise Brown, but lost wide receiver DeAndre Hopkins to a six-game PED suspension.
All times listed are Eastern.
2022 Arizona Cardinals schedule
| Week | Date | Opponent | Time (ET) | TV Channel |
|---|---|---|---|---|
| Week | Date | Opponent | Time (ET) | TV Channel |
| 1 | Sep. 11 | vs. Kansas City Chiefs | 4:25 PM | CBS |
| 2 | Sep. 18 | at Las Vegas Raiders | 4:25 PM | CBS |
| 3 | Sep. 25 | vs. Los Angeles Rams | 4:25 PM | FOX |
| 4 | Oct. 2 | at Carolina Panthers | 4:05 PM | FOX |
| 5 | Oct. 9 | vs. Philadelphia Eagles | 4:25 PM | FOX |
| 6 | Oct. 16 | at Seattle Seahawks | 4:05 PM | FOX |
| 7 | Oct. 20 | vs. New Orleans Saints | 8:15 PM | Prime Video |
| 8 | Oct. 30 | at Minnesota Vikings | 1:00 PM | FOX |
| 9 | Nov. 6 | Seattle Seahawks | 4:05 PM | FOX |
| 10 | Nov. 13 | at Los Angeles Rams | 4:25 PM | FOX |
| 11 | Nov. 21 | vs. San Francisco 49ers (Mexico City) | 8:15 PM | ESPN |
| 12 | Nov. 27 | vs. Los Angeles Chargers | 4:05 PM | CBS |
| 13 | BYE | |||
| 14 | Dec. 12 | vs. New England Patriots (MNF) | 8:15 PM | ESPN |
| 15 | Dec. 18 | at Denver Broncos | 4:05 PM | FOX |
| 16 | Dec. 25 | Tampa Bay Buccaneers (SNF) | 8:20 PM | NBC |
| 17 | Jan. 1 | at Atlanta Falcons | 1:00 PM | FOX |
| 18 | Jan. 7 or 8 | at San Francisco 49ers | TBD | TBD |
Primetime games
Week 7: TNF vs. Saints
Week 11: MNF vs. 49ers (Mexico City)
Week 16: SNF vs. Buccaneers (Christmas night)
Odds on DraftKings Sportsbook
Win total, over/under: 9
Division winner: +330
Conference winner: +1400
Super Bowl odds: +2500
Strength of schedule
2022 win totals: 25
2021 record: 31
The lower the number, the easier the schedule