Here’s the Bills full schedule for the 2021 NFL Season

The NFL announced the complete 2021 schedule on Wednesday, May 12, and the Buffalo Bills are officially set to kick off their 2021 season at home against the Pittsburgh Steelers at 1 PM. Their first divisional game will be in Week 2 against the Miami Dolphins on the road.

The Bills are coming off their best season since the early 1990s, falling in the AFC Championship game to the Kansas City Chiefs. They were able to keep the majority of their roster intact from last year and exercised their fifth-year option on QB Josh Allen and LB Tremaine Edmunds. They released wideout John Brown, but picked up a solid replacement in Emmanuel Sanders to fill that gap and they also brought in Mitch Trubisky to serve as Allen’s backup. In the NFL Draft, they got a younger version of Brown by selecting Houston’s Marquez Stevenson in the sixth round and addressed a huge need in pass rush by taking Miami DE Greg Rosseau in the first round.

All times listed are Eastern.

Odds

Win total, over/under: O 11 (+127), U 11 (-155)
Division champs: -150

Prime time games

Week 5: Oct. 10 at Kansas City Chiefs (SNF) 8:20 PM NBC
Week 6: Oct. 18 at Tennessee Titans (MNF) 8:15 PM ESPN
Week 12: Nov. 25 at New Orleans Saints (Thanksgiving) 8:20 PM NBC
Week 13: Dec. 6 New England Patriots (MNF) 8:15 PM ESPN

Strength of schedule

Super Bowl odds: 12th
2021 win totals: 9th
2020 records: 9th

2021 Schedule

Week 1: Sep. 12 Pittsburgh Steelers 1:00 PM CBS
Week 2: Sep. 19 at Miami Dolphins 1:00 PM FOX
Week 3: Sep. 26 Washington Football Team 1:00 PM FOX
Week 4: Oct. 3 Houston Texans 1:00 PM CBS
Week 5: Oct. 10 at Kansas City Chiefs 8:20 PM NBC
Week 6: Oct. 18 at Tennessee Titans (Mon) 8:15 PM ESPN
Week 7: BYE
Week 8: Oct. 31 Miami Dolphins 1:00 PM CBS
Week 9: Nov. 7 at Jacksonville Jaguars 1:00 PM CBS
Week 10: Nov. 14 at New York Jets 1:00 PM CBS
Week 11: Nov. 21 Indianapolis Colts 1:00 PM CBS
Week 12: Nov. 25 at New Orleans Saints (Thanksgiving) 8:20 PM NBC
Week 13: Dec. 6 New England Patriots (Mon) 8:15 PM ESPN
Week 14: Dec. 12 at Tampa Bay Buccaneers 4:25 PM CBS
Week 15: Dec. 18 or 19 (Sat/Sun) Carolina Panthers TBD
Week 16: Dec. 26 at New England Patriots 1:00 PM CBS
Week 17: Jan. 2 Atlanta Falcons 1:00 PM FOX
Week 18: Jan. 9 New York Jets 1:00 PM CBS

* - Sunday night games in Weeks 5-17 subject to change; Week 18 game TBD
**NFL Network and Amazon simulcast subject to change