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How to watch, what to watch for 49ers vs. Rams in Week 12

The 49ers and Rams face off in Week 12 of the 2020 NFL season. We break down how to watch the game, odds for the matchup, key injuries, and notable fantasy football start/sit considerations.

Los Angeles Rams quarterback Jared Goff (16) drops back to pass during the third quarter against the Tampa Bay Buccaneers at Raymond James Stadium.  Kim Klement-USA TODAY Sports

The Los Angeles Rams have taken control of the NFC West and hav a divisional game against the last place San Francisco 49ers in Week 12. The race for the division title is tight and the leaders have a chance to get a leg up on the competition in what should be an easy matchup.

The Rams’ elite defensive line and secondary have made Russell Wilson and Tom Brady look like below average quarterbacks over the last two weeks and should be able to do the same to Nick Mulllens, who remains Jimmy Garoppolo’s fill-in. Los Angeles’s trio of running backs has taken a backseat to the passing attack. Jared Goff has eclipsed 300 passing yards in three straight games. Whether he can keep that streak going against San Francisco remains to be seen.

The 49ers haven’t scored 20 points in either of Mullens’ last two starts but could get a major boost on offense heading into the weekend. Tevin Coleman and Deebo Samuel are on the mend and could return to action. San Francisco will likely have to be firing on all cylinders to slow down the Rams.

TV Info

Date: Sunday, Nov. 26
Time: 4:05 p.m. ET
Channel: FOX
Broadcast map

Notable Statistical rankings (Football Outsiders)

49ers: #15 Overall — #18 offense, #10 defense, #18 special teams
Rams: #7 Overall — #6 offense, #8 defense, #29 special teams

DraftKings Sportsbook odds

49ers: +6.5, +255
Rams: -6.5, -295
Total: 45

Fantasy football start/sit advice


Richie James, WR, $3,500

You shouldn’t pay up for any 49ers players but James is a cheap play who could return significant value should Samuel (hamstring) and Brandon Aiyuk (Covid-19) be ruled out. San Francisco has drawn up plays for him before and a lack of depth could lead to him being a big part of the game plan again.

Jordan Reed, TE, $3,600

Reed’s role in the offense is growing each week and he could play more snaps than Ross Dwelley on Sunday. He could be one of San Francisco’s few dynamic pass catchers if Aiyuk and Samuel aren’t available to play. The Rams often hold wide receivers to almost nothing so tight ends could be big for San Francisco.


Jared Goff, QB, $6,000

Goff has just begin to hit his stride. While he didn’t perform very well the last time he faced San Francisco, he’ll have home field advantage this time around. His connection with Cooper Kupp is peaking and he’s thrown more than 50 passes twice in his last three games.

Cooper Kupp, WR, $6,400

Kupp notched season-highs in receptions (11) and receiving yards (145). He’s been targeted 40 times over the last three weeks. While Kupp only has two touchdowns this season, his steady stream of targets and ability to rack up yards after the catch can help him make up for his scoring drought.