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How to watch, what to watch for Bills vs. Cardinals in Week 10

The Bills and Cardinals face off in Week 10 of the 2020 NFL season. We break down how to watch the game, odds for the matchup, key injuries, and notable fantasy football start/sit considerations.

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Josh Allen #17 of the Buffalo Bills celebrates a touchdown during the second half against the Seattle Seahawks at Bills Stadium on November 08, 2020 in Orchard Park, New York. Photo by Timothy T Ludwig/Getty Images

Two of the most exciting quarterbacks in the NFL are set to face off in Week 10. Josh Allen and the Buffalo Bills will hit the road to take on Kyler Murray and the Arizona Cardinals. The two dual-threat signal-callers could impress in a game that’s expected to be a shootout.

While the Bills have won three straight games Allen has struggled lately. He recovered from a four-game slump in Week 9 to put on what was arguably his best performance of the season. While the passing game is Buffalo’s bread and butter the emergence of Zack Moss has made the AFC East leaders even more dynamic on offense. The Bills’ defense has been a mess though and could forfeit a ton of points to the Cardinals.

Murray ranks eighth in rushing yards with 543 and has eight rushing scores as well. Only Lamar Jackson has a chance to catch him in terms of ground yardage among quarterbacks this season, and the addition of DeAndre Hopkins has made him even more dangerous. Arizona might not be at full strength if Kenyan Drake is ruled out for a second straight game with an ankle injury but Chase Edmonds is capable of replacing his production.

TV Info

Date: Sunday, Nov. 15
Time: 4:05 p.m. ET
Channel: CBS
Stream: FuboTV
Broadcast map

Notable Statistical rankings (Football Outsiders)

Bills: #13 overall — #10 offense, #17 defense, #8 special teams
Cardinals: #11 overall — #9 offense, #10 defense, #23 special teams

DraftKings Sportsbook odds

Bills: +2, +110
Cardinals: -2, -125
Total: 56.5

Fantasy football start/sit advice


Josh Allen, Quarterback, $7,500

Allen had a resurgent game against the Seattle Seahawks and tallied a season-high 39 DKFP. He threw for three scores and ran for one as well. Only Murray can match Allen’s upside in this matchup and one of the two quarterbacks while likely use their athleticism to be this contest’s top scorer.

Stefon Diggs, Wide Receiver, $7,500

Diggs leads the NFL with 91 targets and will be up against yet another below average secondary. His upside isn’t as high as Allen’s but he’s been more consistent. Stacking him with Allen will be pricy but could be well worth the risk.


Kyler Murray, Quarterback, $8,000

Murray has the highest DKFP average on the main slate and his ridiculous rushing upside makes up for his interception problem. Murray has only failed to run for a score in one game this season. Murray could very well end up as the most productive fantasy player in the NFL this year and is up against a Bills defense that tanks 31st against quarterbacks on DraftKings.

Chase Edmonds, Running Back, $6,300

Edmonds fell short of expectations in Week 9 but racked up 28 touches. If Drake misses a second straight game Edmonds should get absurd usage again. His versatility and expected level of exposure makes him worth playing over DeAndre Hopkins ($7,700 in my opinion. Both could be quality plays, but Edmonds could give you more bang for your buck.