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Pick against the spread for Rams vs. Cardinals in Week 12 of 2023 NFL season

Henry Palattella gives their pick against the spread for Rams vs. Cardinals in Week 12.

Los Angeles Rams running back Kyren Williams gestures for a first down after a play in the second half of an NFL football game between the Arizona Cardinals and Los Angeles Rams at SoFi Stadium, October 15, 2023, in Inglewood, California. Photo by Tony Ding/Icon Sportswire via Getty Images

The Los Angeles Rams (4-6) will look to keep their slim playoff hopes alive when they travel to Arizona on Sunday to take on the Cardinals (2-9). Kickoff is scheduled for 4:05 p.m. ET.

The Rams are 1.5-point favorites at DraftKings Sportsbook, while the total is set at 44.5

Rams vs. Cardinals, Week 12: Pick against the spread

The Rams offense gets a big boost this week with the return of leading rusher Kyren Williams, who is returning from a four-week absence due to a sprained ankle. Williams rushed for 456 yards in six games prior to getting injured, with his best performance coming in the form of a 158-yard performance against the Cardinals in his last game prior to getting injured. The Rams are 3-1 against the NFC West this season and have won 12 of 14 against Arizona. With Cooper Kupp dealing with an ankle injury, expect a heavy dose of Williams against the Cardinals.

Sunday’s game will be Kyler Murray’s third start this season after he missed the start of the season with a torn ACL. Murray’s gone 1-1 as a starter and is coming off a loss to the Texans where he threw for 214 yards and a touchdown. Murray and the Cardinals were playing from behind for most of the afternoon thanks to Arizona’s defense giving up 21 points and 333 yards in the first half. While the Cardinals will be without leading tackler Kyzir White, they’ll have defensive backs Budda Baker and Jalen Thompson, both of whom missed the Rams’ 26-9 win over Arizona earlier in the year.

The Pick: Rams -1.5

The Rams are the better team and I expect that to make the difference Sunday. The Cardinals went toe-to-toe against a potential playoff team last week on the road, but Sean McVay and Matthew Stafford have had the Cardinals' number since heading out to Hollywood. Williams’ return is the difference here.