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Pick against the spread for 49ers vs. Seahawks in Week 12 of 2023 NFL season

Ben Hall gives their pick against the spread for 49ers vs. Seahawks in Week 12.

San Francisco 49ers wide receiver Deebo Samuel (19) congratulates San Francisco 49ers wide receiver Brandon Aiyuk (11) for catching a touchdown pass against the Pittsburgh Steelers during the first half at Acrisure Stadium.  Gregory Fisher-USA TODAY Sports

The San Francisco 49ers and Seattle Seahawks will matchup in a NFC West matchup on Thanksgiving. This is an important matchup as Seattle sits just one game behind the 49ers for first place in the division. Kickoff from Lumen Field is set for 8:20 p.m. ET and will air on NBC.

San Francisco is a 7-point favorite at DraftKings Sportsbook and the total sits at 44. On the moneyline, the 49ers are -345 while the Seahawks are +275.

49ers vs. Seahawks, Week 12: Pick against the spread

There was a time this season when many overreacted on the 49ers because of the injuries they were dealing with. They got health again and look like the team to beat in the NFL. It was a tough loss for them as Talanoa Hufanga suffered a torn ACL last week against the Tampa Bay Buccaneers. However, their offense is back to 100%. When Trent Williams is on the field, this team is dominant.

Seattle is in a terrible spot right now. They’re coming off a terrible loss to the Los Angeles Rams and Geno Smith and Kenneth Walker suffered injuries in the game. Smith has a good chance to play on Thursday, but Walker will not. That is a major blow to this offense who is facing the toughest defense they have all season. They will be in trouble for this matchup.

The Pick: 49ers -7

Getting Williams back on this offensive line has changed everything for the 49ers. Without him, they looked lost. But now that he’s back, this team is back to looking as dominant as they were at one point. He is the key factor for how far this team can go. Even though this is a road matchup, I like the 49ers to win handily. Smith won’t be at 100% if he does play and you ave to think that the 49ers front will be getting after him. Watch for a big road win for San Francisco.