clock menu more-arrow no yes mobile

Filed under:

Chargers vs. 49ers: Game picks, best bets for Week 10 Sunday Night Football

We take a look at the best bets available for the Chargers vs. 49ers Week 10 matchup available on DraftKings Sportsbook, including our favorite player prop.

Christian McCaffrey #23 of the San Francisco 49ers rushes during the game against the Los Angeles Rams at SoFi Stadium on October 30, 2022 in Inglewood, California. The 49ers defeated the Rams 31-14. Photo by Michael Zagaris/San Francisco 49ers/Getty Images

We are in Week 10 of the NFL season. This week’s edition of Sunday Night Football will feature the Los Angeles Chargers will hit the road for a non-conference matchup against the San Francisco 49ers. Kickoff from Levi’s Stadium in Santa Clara, California is set for 8:20 p.m. ET, and the game will air on NBC.

Here, we’ll take a look at our picks for best bets for Chargers vs. 49ers in Week 10 of the NFL season.

All odds come courtesy of DraftKings Sportsbook.

Chargers vs. 49ers odds

Spread: 49ers -7
Point total: 45.5
Moneyline: Chargers +250, 49ers -300

Our picks, best bets

Pick against the spread: 49ers -7

The 49ers are at home and are getting a boost coming out of their bye week. They have now had ample time to get star running back Christian McCaffrey up to speed and should see their offense take a step forward with a healthy Deebo Samuel returning. The Chargers have injury problems of their own, and they will be too much to overcome. Even though it is a seven-point spread, I think San Francisco covers at home.

Over/under: Over 45.5

As good as the outlook for San Francisco is, their defense has been known to give up points. While the Chargers could be without Keenan Allen and Mike Williams, that doesn't mean that they will be kept off the scoreboard. We know the scoring potential of the 49ers, so I think we see the over hit in this game.

Player prop: TBD