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MLB lineups for Friday, April 21: Mookie Betts returns (but not at shortstop)

We provide updates on MLB lineup news, providing fantasy baseball and betting analysis on Friday, April 21.

Los Angeles Dodgers right fielder Mookie Betts looks on during a regular season game between the New York Mets and Los Angeles Dodgers on April 17, 2023 at Dodger Stadium in Los Angeles, CA. Photo by Brandon Sloter/Icon Sportswire via Getty Images

After a light travel day on Thursday, all 30 MLB teams are back in action on Friday — with 14 night games and just one matinee at Wrigley Field. That means lots of start/sit decisions for fantasy baseball managers, as injuries have really taken their toll around the league. Luckily, our daily lineup report is here to help you keep track of who’s in and who’s out.

MLB starting lineups: Friday, April 21

Los Angeles Dodgers vs. Chicago Cubs, 2:20 p.m. ET

Alas, it would appear that the Mookie Betts shortstop experiment was a short-lived one, at least for now — he’s back in right field and leading off for L.A, while Trayce Thompson and Luke Williams start in center and short, respectively.

Patrick Wisdom will DH as Nick Madrigal gets a start at third and Eric Hosmer has the day off against lefty Julio Urias.

Cincinnati Reds vs. Pittsburgh Pirates, 6:35 p.m. ET

Not much changes for the Reds, with Spencer Steer in the lineup again and Jason Vosler at first base.

Connor Joe and Jack Suwinski continue to hold down Pittsburgh’s outfield and swing very hot bats, while Mark Mathias will play second and Rodolfo Castro handles short.

Chicago White Sox vs. Tampa Bay Rays, 6:40 p.m. ET

Business as usual for the White Sox, as Jake Burger continues to start at third base. Andrew Benintendi will lead off and Yasmani Grandal catches.

A righty on the mound for Chicago means lefties Josh Lowe and Luke Raley will start for Tampa, while Isaac Paredes plays third and Harold Ramirez serves as the DH.

Detroit Tigers vs. Baltimore Orioles, 7:05 p.m. ET

Nick Maton leads off again while Kerry Carpenter cleans up and Matt Vierling starts in left. Jonathan Schoop will play second base for Detroit.

No Jorge Mateo in the lineup tonight as he battles hip tightness, meaning Gunnar Henderson shifts to short and Ramon Urias plays third.

Colorado Rockies vs. Philadelphia Phillies, 7:05 p.m. ET

Willi Castro gets a start at second base tonight for Colorado while Charlie Blackmon is back in the DH spot and Alan Trejo takes shortstop over Ezequiel Tovar.

Philly welcomes Edmundo Sosa back to the lineup, as he’ll start at third base while Jake Cave continues to start against righties.

Toronto Blue Jays vs. New York Yankees, 7:05 p.m. ET

Brandon Belt gets a start at first while Cavan Biggio plays second base for Toronto and Alejandro Kirk gets a night off.

Anthony Volpe appears entrenched as New York’s leadoff man right now, as Oswald Peraza starts at third and Isiah Kiner-Falefa is back in center with another lefty on the mound.

Miami Marlins vs. Cleveland Guardians, 7:10 p.m. ET

No Avisail Garcia while Jesus Sanchez gets a start in the outfield for Miami. Jorge Soler will DH.

The struggling Josh Naylor drops all the way to eighth tonight despite a righty on the mound as Josh Bell will DH and Amed Rosario returns to the lineup at short.

Houston Astros vs. Atlanta Braves, 7:20 p.m. ET

Mauricio Dubon leads off again while Corey Julks plays left and Jake Meyers gets the start in center for Houston.

Marcell Ozuna sits again as Kevin Pillar gets another start in left while the red-hot Sam Hilliard mans center field.

Oakland Athletics vs. Texas Rangers, 8:05 p.m. ET

Esteury Ruiz leads off again while Connor Capel starts in right, Aledmys Diaz plays second and Tony Kemp patrols left for Oakland.

Robbie Grossman will take his turn in the two-hole for Texas, while Bubba Thompson and Leody Taveras hold down left and center, respectively. Josh Smith and Travis Jankowski get days off.

Washington Nationals vs. Minnesota Twins, 8:10 p.m. ET

Stone Garrett continues to start in left, this time sending Alex Call to the bench. Keibert Ruiz is up to second in the batting order.

Jorge Polanco is officially back as the Twins’ second baseman, as Eduoard Julien was sent down to Triple-A. Polanco will bat fifth tonight.

Boston Red Sox vs. Milwaukee Brewers, 8:10 p.m. ET

It’s Boston’s standard lineup against a lefty, as Yu Chang, Enrique Hernandez and Jarren Duran get starts up the middle.

Owen Miller gets the start at third while Jesse Winker DHs for Milwaukee.

Kansas City Royals vs. Los Angeles Angels, 9:38 p.m. ET

Michael Massey is up to fifth in the lineup while Edward Olivares serves as the DH and Jackie Bradley Jr. gets a start in left.

No Mike Trout tonight in what is hopefully just a routine day off. Luis Rengifo will handle center field while Anthony Rendon moves to third in the lineup.

San Diego Padres vs. Arizona Diamondbacks, 9:40 p.m. ET

It’ll be Nelson Cruz rather than Matt Carpenter at DH for San Diego tonight, while Fernando Tatis Jr. leads off again and Brett Sullivan catches.

Corbin Carroll: three-hole hitter. Gabriel Moreno is back behind the dish for Arizona while Pavin Smith serves as the DH and Jake McCarthy sits.

St. Louis Cardinals vs. Seattle Mariners, 10:10 p.m. ET

No Tyler O’Neill or Dylan Carlson tonight for St. Louis, as Alec Burleson plays left, Nolan Gorman starts at DH and Jordan Walker will handle right with Lars Nootbaar in center.

Tom Murphy starts behind the dish over Cal Raleigh against a lefty and Jose Caballero makes yet another start at second base for Kolten Wong.

New York Mets vs. San Francisco Giants, 10:15 p.m. ET

Francisco Alvarez and Brett Baty are back in the lineup for New York, with Luis Guillorme at second and Jeff McNeil in right. Daniel Vogelbach will serve as the DH.

It’s the usual lineup against a lefty for the Giants, with Thairo Estrada leading off followed by Wilmer Flores, Darin Ruf, J.D. Davis and David Villar. Joey Bart will catch and Heliot Ramos starts in left with Brett Wisely in center.