Clemson (2-2, 0-2 ACC) is off to a tough start in conference play after losses to FSU and Duke. They took Florida State to overtime in Week 4, but ultimately lost, 31-24. Quarterback Cade Klubnik passed for one TD and rushed for another. He passed for 283 yards, and Will Shipley and Phil Mafah combined for 137 yards on the ground in the loss.
Syracuse (4-0, 0-0 ACC) grabbed wins over Purdue and Army in the last two weeks to remain undefeated. The Orange beat Army 29-16 in Week 4, and quarterback Garrett Shrader showed off his dual-threat strength, going 21-for-26 for 245 yards and a touchdown, and rushing for another 50 yards and a touchdown. LeQuint Allen had 104 rushing yards and a score.
Clemson vs. Syracuse
Date: Saturday, September 30
Start time: 12:00 p.m. ET
TV channel: ABC/ESPN3
Live stream: WatchESPN
Odds from DraftKings Sportsbook
Spread: Clemson -7
Moneyline: Clemson -305, Syracuse +245