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Opening odds for Week 16 of the NFL season

We’ve got an early look at Week 16 point spreads as the NFL wraps up Week 15.

San Francisco 49ers v Arizona Cardinals Photo by Christian Petersen/Getty Images

The NFL is headed into Sunday Night Football and has Monday Night Football still to play, but we’ve got some early odds to get you ready for Week 16. The upcoming slate has some pivotal games with major playoff implications — including the San Francisco 49ers vs. Baltimore Ravens on MNF, the Dallas Cowboys vs. the Miami Dolphins and the Browns battle the Texans.

DraftKings Sportsbook unveiled opening odds for all 18 weeks back in May after the schedule was released. Those were pulled once the regular season got underway and the sportsbook re-opened the lines for Week 16 with a lookahead line last week. Below, we’ve included the offseason opening odds, the lookahead line, and the current line once it re-opens.

Here’s our full list of Week 16 odds at DraftKings Sportsbook. We’ll update once the odds re-open Sunday evening.

Saints vs Rams

Sunday, December 17

Point spread: Rams -3.5
Point total: 44.5
Moneyline: Rams -185, Saints +154

Wednesday, December 13

Point spread: Rams -4
Point total: 44.5
Moneyline: Rams -192, Saints +160

May 12

Point spread: Rams -1
Moneyline: Rams -115, Saints -105

The Rams' offense has been humming lately, especially with the return of Kyren Williams. They should be able to keep that rolling against a Saints team that bounced back nicely offensively behind Derek Carr and Alvin Kamara. Expect New Orleans to get Chris Olave back, but that probably won’t matter much as the Rams should be able to win and cover as they rage toward securing a playoff spot.

Pick: Rams -3.5

Bengals vs. Steelers

Sunday, December 17

Point spread: Steelers -1
Point total: 40
Moneyline: Steelers -112, Bengals -108

Wednesday, December 13

Point spread: Steelers -1.5
Point total: 39.5
Moneyline: Steelers -122, Bengals +102

May 12

Point spread: Bengals -2.5
Moneyline: Bengals -130, Steelers +110

The Bengals and Steelers get a second straight week of Saturday football. In Week 14, the Bengals beat the Vikings in overtime while the Steelers blew a 13-0 lead and lost handily 30-13. Cincinnati improved to 8-6 and moved a game up on Pittsburgh in the playoff standings.

Jake Browning is proving to be for real and the Bengals have enough firepower around him to make up for a rather shaky defense. They’re not going deep in January with this defense, but they have enough to handle a struggling Steelers squad. Pittsburgh benched Mitchell Trubisky amidst his struggles and went to Mason Rudolph. This won’t be a blowout, but I’ll take the Bengals to win a fourth straight and cover.

Pick: Bengals +1

Bills vs. Chargers

Sunday, December 17

Point spread: Bills -13
Point total: 42.5
Moneyline: Bills -850, Chargers +575

Wednesday, December 13

Point spread: Bills -9.5
Point total: 40.5
Moneyline: Bills -410, Chargers +320

May 12

Point spread: Bills -1
Moneyline: Bills -115, Chargers -105

The Bills had one of the toughest stretches in the NFL in their last three games and went 2-1 against the Eagles, Niners, and Cowboys. They defeated Dallas 31-10 in Week 15 and are looking more and more like a playoff team. Now at 8-6, the Bills are in play for a Wild Card berth in the AFC.

The Chargers suffered a brutal loss to the Raiders in Week 15, falling 63-21 with backup Easton Stick coming in for an injured Justin Herbert. The Chargers parted ways with head coach Brandon Staley after the game. They now sit at 5-9 for the season, and Herbert is out for the remainder of the year. The Bills won’t have much trouble in this matchup as they set their sights on a playoff run.

Pick: Bills -13

Browns vs. Texans

Sunday, December 17

Point spread: Texans -2.5
Point total: 42.5
Moneyline: Texans -135, Browns +114

Wednesday, December 13

Point spread: Texans -1.5
Point total: 41
Moneyline: Texans -122, Browns +102

May 12

Point spread: Browns -4
Moneyline: Browns -190, Texans +160

The Browns just barely pulled off a win over the Bears, grabbing a walk-off end zone interception to win 20-17. Joe Flacco started for the Browns and threw three interceptions in the win. The Browns also grabbed two picks off of Justin Fields. With the win, the Browns sit at 9-5 and currently hold the fifth seed in the AFC playoff standings.

The Texans grabbed an overtime win over the Titans in Week 15, 19-16. With the win, they move to 8-6 and currently sit just outside the bubble in the AFC. Backup Case Keenum took over for CJ Stroud this week after Stroud sustained a head injury that kept him sidelined following Week 14. Keenum finished with one touchdown and one interception.

Pick: Texans -2.5

Colts vs. Falcons

Sunday, December 17

Point spread: Falcons -1
Point total: 45
Moneyline: Falcons -115, Colts -105

Wednesday, December 13

Point spread: Falcons -1.5
Point total: 43
Moneyline: Falcons -122, Colts +102

May 12

Point spread: Falcons -2.5
Moneyline: Falcons -130, Colts +110

Indianapolis keeps on finding ways to get it done with a banged-up roster and it ran over Pittsburgh in a 30-13 victory on Saturday. The team won despite losing Zack Moss and Michael Pittman Jr. On the other side, Atlanta suffered an embarrassing 9-7 loss to Carolina on Sunday and the calls for Arthur Smith’s job are growing louder. The Falcons are in desperation mode now as they are sitting a game back in the NFC South standings.

Despite the uncertainty over Moss and Pittman’s status, I’ll lean towards the Colts covering and winning on the road here. I do not trust the Falcons and this is looking like a late-season collapse on their end.

Pick: Colts +1

Lions vs. Vikings

Sunday, December 17

Point spread: Lions -4.5
Point total: 47
Moneyline: Lions -218, Vikings +180

Wednesday, December 13

Point spread: Lions -3
Point total: 46
Moneyline: Lions -148, Vikings +124

May 12

Point spread: Vikings -1
Moneyline: Vikings -115, Lions -105

The Lions and Vikings meet with the NFC North title potentially on the line. Both teams played on Saturday in Week 14 to set this one up. The Vikings lost in overtime to the Bengals to open the Saturday slate and the Lions crushed the Broncos to close the day. Detroit moved to three games up with three games remaining.

Detroit was efficient in their win over Denver, with Jared Goff playing his best game of the year. He threw five touchdown passes on 278 yards. Minnesota took a 17-3 lead over Cincinnati but collapsed as Nick Mullens does not look like any short-term answer. The Vikings shouldn’t get blown out in this one, but I’ll lay the points with a much better Lions squad.

Pick: Lions -4.5

Commanders vs. Jets

Sunday, December 17

Point spread: Jets -3
Point total: 40
Moneyline: Jets -162, Commanders +136

Wednesday, December 13

Point spread: Jets -3
Point total: 40
Moneyline: Jets -162, Commanders +136

May 12

Point spread: Jets -5.5
Moneyline: Jets -215, Commanders +185

The Commanders put up a fight against the Rams but lost 28-20 to move to 4-10 on the season. Backup quarterback Jacoby Brissett passed for two touchdowns after coming in for Sam Howell, but the Washington defense could not contain the Rams’ Kyren Williams. Ron Rivera finds himself on the hot seat.

The Jets fell to the Dolphins in a 30-0 shutout in Week 15, effectively ending any playoff hopes as they near elimination. Quarterback Zach Wilson sustained a head injury in the loss, and QB Trevor Siemian threw two interceptions. The Jets will pivot to looking ahead to the 2024 season at this point.

Neither team particularly wants to win this game as they each jockey for a high draft pick in 2024, but the Jets' defense is better than the Commanders' defense. I’m riding with New York at home.

Pick: Jets -3

Seahawks vs. Titans

Sunday, December 17

Point spread: Seahawks -2.5
Point total: 43.5
Moneyline: Seahawks -142, Titans +120

Wednesday, December 13

Point spread: Seahawks -2
Point total: 44
Moneyline: Seahawks -125, Titans +105

May 12

Point spread: Seahawks -2
Moneyline: Seahawks -125, Titans +105

The Seahawks face the Eagles on Monday Night Football in Week 15. Geno Smith is questionable to play after missing last week’s game. Drew Lock took over under center against the Niners in Week 14 and passed for two touchdowns and two interceptions. Seattle currently sits outside the playoff bubble in the NFC.

The Titans lost to the Texans in overtime, 19-16. Will Levis passed for 199 yards and an interception before sustaining a leg injury in the final moments of the game. With the loss, the Titans move to 5-9, sitting at the bottom of the AFC South. While they are not technically eliminated from the playoffs quite yet, Tennessee will not be seeing the postseason.

Pick: Seahawks -2

Packers vs. Panthers

Sunday, December 17

Point spread: Packers -3.5
Point total: 36.5
Moneyline: Packers -180, Panthers +150

Wednesday, December 13

Point spread: Packers -4.5
Point total: 36
Moneyline: Packers -230, Panthers +190

May 12

Point spread: Packers -1
Moneyline: Packers -115, Panthers -105

Green Bay dropped its second straight game on Sunday, falling to Tampa Bay in a 34-20 setback at home. As a result, the Packers have officially been eliminated from NFC North title contention and are now sitting on the outside in the NFC Wild Card picture. Meanwhile, Carolina managed to pick up its second win of the year in a 9-7 upset of Atlanta. Bryce Young marched the Panthers down the field on a 17-play drive to set up a game-winning field goal for Eddy Pineiro.

Green Bay is in desperation mode and a loss here may be a death sentence for its fleeting playoff hopes. The Panthers are still the Panthers and I’ll take the Packers to both cover and win here.

Pick: Packers -3.5

Jaguars vs. Buccaneers

Sunday, December 17

Point spread: Jaguars -2.5
Point total: 45
Moneyline: Jaguars -135, Bucs +114

Wednesday, December 13

Point spread: Jaguars -2.5
Point total: 44.5
Moneyline: Jaguars -130, Bucs +110

May 12

Point spread: Jaguars -3.5
Moneyline: Jaguars -180, Bucs +155

The Jaguars face the Ravens on Sunday Night Football. Their 8-5 record currently has them sitting atop the AFC South. They are currently on a two-game losing streak after falling to the Browns in Week 14. Trevor Lawrence threw three interceptions in the loss.

The Buccaneers grabbed a 34-20 win over the Packers in Week 15 to move to 7-7 and take the lead in the NFC South. It’s still a close race in the division, so they haven’t quite clinched the title and playoff berth yet. Baker Mayfield passed for four touchdowns against Green Bay, and the Bucs’ defense successfully shut down the Packers’ ground game.

Pick: Bucs +2.5

Cowboys vs. Dolphins

Sunday, December 17

Point spread: Dolphins -2
Point total: 51
Moneyline: Dolphins -130, Cowboys +110

Wednesday, December 13

Point spread: Dolphins -1.5
Point total: 52
Moneyline: Dolphins -122, Cowboys +102

May 12

Point spread: Dolphins -1.5
Moneyline: Dolphins -125, Cowboys +105

The Cowboys suffered a tough loss to the Bills in Week 15, falling 31-10. Dak Prescott passed for 134 yards and an interception. Despite the loss, the Cowboys clinched a spot in the playoffs this week, and are in the running for the NFC East title.

The Dolphins shut out the Jets in Week 15, 30-0, to move to 10-4. Tua Tagovailoa passed for one touchdown, and Raheem Mostert added two on the ground. They have not yet clinched a spot in the playoffs, but are the frontrunners to win the AFC East.

Pick: Cowboys +2

Cardinals vs. Bears

Sunday, December 17

Point spread: Bears -3
Point total: 44
Moneyline: Bears -155, Cardinals +130

Wednesday, December 13

Point spread: Bears -3
Point total: 43.5
Moneyline: Bears -155, Cardinals +130

May 12

Point spread: Bears -4.5
Moneyline: Bears -195, Cardinals +165

The Cardinals kept it close with the 49ers for the first half, but the Niners ran away in the second half of Week 15 to hand Arizona a 45-29 loss. Kyler Murray passed for a touchdown and two interceptions. With the loss, the Cardinals move to 3-11 and will be looking forward to 2024 changes as they jockey for a high draft pick.

The Bears came oh-so-close to defeating the Browns, taking a third-quarter lead that was erased in the fourth quarter. The Bears’ defense grabbed three interceptions from Joe Flacco, and Justin Fields put up a Hail Mary attempt that almost gave the Bears the win. The pass slipped out of the hands of Darnell Mooney, and the Bears moved to 5-9 with the loss. The Bears have been showing signs of life lately, and they have the first pick of the draft essentially locked up whether they win or lose.

Pick: Bears -3

Patriots vs. Broncos

Sunday, December 17

Point spread: Broncos -5.5
Point total: 37
Moneyline: Broncos -238, Patriots +195

Wednesday, December 13

Point spread: Broncos -5.5
Point total: 36
Moneyline: Broncos -218, Patriots +180

May 12

Point spread: Broncos -1.5
Moneyline: Broncos -120, Patriots +100

The Broncos and Patriots provide a less-than-stellar Sunday evening matchup. Denver lost an ugly one to the Lions on Saturday, giving up five touchdown passes to Jared Goff in a 42-17 loss. Denver had won six of seven before that and the loss was a big one for their playoff chances.

They face a Patriots squad that lost 27-17 to the Chiefs and is playing out the string. Given Denver is playing at home, I’m inclined to lay the points. Your better bet is to stay away from this one.

Pick: Broncos -5.5

Raiders vs. Chiefs

Sunday, December 17

Point spread: Chiefs -10
Point total: 42.5
Moneyline: Chiefs -500, Raiders +380

Wednesday, December 13

Point spread: Chiefs -10.5
Point total: 42
Moneyline: Chiefs -500, Raiders +380

May 12

Point spread: Chiefs -8.5
Moneyline: Chiefs -380, Raiders +310

Las Vegas opened the gates of hell on Los Angeles on Thursday night, stomping the Chargers in a 63-21 blowout that got HC Brandon Staley and GM Tom Telesco fired the next morning. That victory kept the Raiders postseason hopes alive for another week. Meanwhile, Kansas City avoided its first three-game losing streak of the Patrick Mahomes era with a 27-10 road win over New Orleans on Sunday. That victory kept the Chiefs in the hunt for the No. 1 seed in the AFC.

Kansas City is closing in on another AFC West title and currently owns a six-game winning streak against the Raiders. I think they make it seven and win here in what should be a festive environment on Christmas afternoon at Arrowhead.

Pick: Chiefs -10

Giants vs. Eagles

Sunday, December 17

Point spread: Eagles -10
Point total: 43.5
Moneyline: Eagles -520, Giants +390

Wednesday, December 13

Point spread: Eagles -10.5
Point total: 44
Moneyline: Eagles -500, Giants +380

May 12

Point spread: Eagles -7
Moneyline: Eagles -295, Giants +245

The Giants saw their magical run take a hit as they lost to the Saints on Sunday. They dropped to 5-9 and they head into Week 16 on the verge of elimination from the playoff picture. They face an Eagles squad that closes out Week 15 with a road game against the Seahawks on Monday Night Football.

Philly avoids the short week thanks to their inclusion in the Christmas tripleheader. Jalen Hurts is dealing with an illness that could still keep him from playing against the Seahawks, but it seems unlikely to extend into Week 16. The Giants had a nice little run, but the reality is setting in on the Tommy DeVito experience. Lay the points with the Eagles.

Pick: Eagles -10

Ravens vs. 49ers

Sunday, December 17

Point spread: 49ers -4
Point total: 45.5
Moneyline: 49ers -192, Ravens +160

Wednesday, December 13

Point spread: 49ers -4.5
Point total: 45
Moneyline: 49ers -205, Ravens +170

May 12

Point spread: 49ers -3
Moneyline: 49ers -150, Ravens +130

The Ravens take on the Jaguars on Sunday night in Week 15. They currently sit atop the AFC North and are looking for a division title. The Ravens most recently defeated the Rams in overtime.

The Niners let the Cardinals hang around for a while in Week 15 but ran away with the game in the second half for a 45-29 win. Brock Purdy passed for four touchdowns in the win. This game could determine the seeding in the AFC playoffs, and the Niners have already clinched a berth in the postseason. It’s very, very hard to beat San Francisco at home, so I’m riding with the Niners and the points.

Pick: 49ers -4