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Best DFS lineup strategy for 49ers-Seahawks on Thanksgiving

The 49ers and Seahawks face off on Thanksgiving to open Week 12. We take a look at the best plays for the DK Showdown.

Tampa Bay Buccaneers v San Francisco 49ers Photo by Ezra Shaw/Getty Images

The Seattle Seahawks will host the San Francisco 49ers in the primetime nightcap of the NFL Thanksgiving slate. Kickoff from Lumen Field in Seattle, WA is scheduled for 8:20 p.m. ET on Thursday, November 23.

Below, we’ll break down our top DraftKings NFL DFS value plays and strategy for the single game showdown slate focusing on the 49ers vs. Seahawks.

NFL DFS Showdown strategy: 49ers vs. Seahawks

Captain’s Picks

Christian McCaffrey, RB, 49ers ($18,000)

It’s easy to say that McCaffrey is the most reliable DFS play on this slate. He’s averaging a steady 25.3 FPPG this season, and the Seahawks have allowed the sixth-most fantasy points to opposing running backs this season. CMC has hauled in at least five receptions in three straight games while catching two touchdown passes over that span. Seattle has had trouble in that department while giving up the fifth-most receiving yards per game (44) to the running back position.

Zach Charbonnet, RB, Seahawks ($10,500)

Seattle RB Kenneth Walker III is highly questionable for this game after suffering an oblique injury at the Rams last week. You can check on updates to his status here. If Walker is ruled out, then Charbonnet figures to serve as the Seahawks’ RB1, as he took over for 15 rush attempts, 47 yards and 6 catches on 6 targets for 22 yards in relief of Walker last week. The matchup isn’t great overall, but Charbonnet figures to see significant volume. Teams have had more success running than passing on San Francisco, as the 49ers rank 23rd in DVOA against the run compared to sixth in pass DVOA.

FLEX Options

Brock Purdy, QB, 49ers ($10,000)

Purdy had a perfect passer rating last week against the Tampa Bay Buccaneers while going 21-for-25 with 333 yards, three touchdowns, and no interceptions. That produced 29.72 fantasy points, which marked his third-straight game with at least 23.8 FP. Purdy will look to keep his groove against a Seattle defense that ranks 25th in DVOA against the pass, so this sets up as a nice opportunity for the 49ers QB to keep going.

George Kittle, TE, 49ers ($7,400)

Kittle was feast-or-famine from a fantasy perspective to begin the season, but he has really turned things around in the last month with 23+ fantasy points in three straight games. We know he has a strong connection with Purdy, which goes back to a fantastic stretch of games in late 2022. Kittle is hitting his stride in the second half of this year as well, and now he’s facing a Seattle team that ranks 23rd in DVOA to the tight end position.

Players to Avoid

Deebo Samuel, WR, 49ers ($8,000)

Brandon Aiyuk has been the top receiver for San Francisco this season, and Kittle is soaking up a ton of looks through the air as well. That leaves Samuel delegated to a smaller role than usual, as he has caught 7-of-8 targets for 93 yards combined in the last two games. He does have a rushing touchdown in that span, but has otherwise been relatively quiet. There’s a chance that Samuel will break out at some point, but we aren’t catching much of a discount on DraftKings despite his slump. I would rather look towards Kittle for a smaller salary.

Geno Smith, QB, Seahawks ($9,400)

Smith suffered an elbow injury last week against the Rams, but he was able to return to the game. Earlier in the week, head coach Pete Carroll said that Smith should be able to play on Thanksgiving, but you can stay in the loop with our updates here. If Smith plays, it’s tough to endorse him at a $9,400 salary against a top-notch San Francisco defense that ranks 6th in DVOA against the pass while allowing the third-fewest fantasy points to opposing signal-callers.