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Pick against the spread, over/under for Cavaliers vs. 76ers on Tuesday, November 21

We go over some of the best betting options for Tuesday’s matchup between the Cavaliers and 76ers.

Philadelphia 76ers v Brooklyn Nets
Joel Embiid of the Philadelphia 76ers reacts in the second half against the Brooklyn Nets at Barclays Center on November 19, 2023 in the Brooklyn borough of New York City. The Philadelphia 76ers defeated the Brooklyn Nets 121-99.
Photo by Elsa/Getty Images

The Cleveland Cavaliers (7-6) will attempt to keep their winning streak going when they meet the red-hot Philadelphia 76ers (10-3) Tuesday night in a contest of two Eastern Conference playoff teams from a year ago. The Cavaliers have won their last three games to get above .500, while the 76ers are winners in their last two.

Donovan Mitchell is out for the Cavaliers with a hamstring injury, while Caris LeVert is questionable with a knee issue. The 76ers are intact on the day-to-day injury front, but remain without Kelly Oubre Jr. due to his fractured ribs.

The 76ers are 8-point favorites at DraftKings Sportsbook, with the total coming in at 218.5. Philadelphia is -325 on the moneyline while Cleveland is +260.

Cavaliers vs. 76ers, 7:30 p.m. ET

Pick ATS: 76ers -8

Philadelphia has won the last two contests by double digits and now gets to face a Cleveland side without its best player. The 76ers are 10-3 ATS, and they’ve only failed to cover the spread once in victories. The Cavaliers are 5-8 ATS, but do have a 2-1 mark as a road underdog. Even though this is a significant number, take the 76ers to get another win at home.

Over/Under: Over 218.5

These teams are actually somewhat average when it comes to defense. The 76ers are 11th in defensive rating and 13th in points allowed per game, while the Cavaliers are 12th in defensive rating and tied for 11th in points allowed per game. Meanwhile, Philadelphia’s offense has been on fire at 120.5 points per game this season. Even with Mitchell sidelined, the Cavaliers are going to have to put up points to keep up in Philly. Take the over on this slightly lower total.