Notre Dame (5-1) fell to Ohio State in a heartbreaker at home in Week 4, but avoided the same fate in Week 5 as they staged a last-minute drive down the field to beat Duke, 21-14. Running back Audric Estime scored both touchdowns for the Irish, and tight end Mitchell Evans has been a breakout star in the last two games with 209 combined receiving yards in the last two weeks.
Louisville (5-0, 3-0 ACC) has been one of the ACC’s most interesting teams this season. Still undefeated after holding on against NC State in Week 5, the Cardinals have inched into the top 25 ahead of one of the biggest games of their season. Quarterback Jack Plummer is at the center of the operation, with 11 passing touchdowns and six interceptions so far this season. Jamari Thrash is the team’s top WR, and Jawhar Jordan leads the rushing game.
Notre Dame vs. Louisville
Date: Saturday, October 7
Start time: 7:30 p.m. ET
TV channel: ABC
Live stream: WatchESPN
Odds from DraftKings Sportsbook
Spread: Notre Dame -6.5
Moneyline: Notre Dame -250, Louisville +205